PROX1

Prospero-related homeobox 1
Identifiers
Symbols	PROX1 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2069
Gene ontology
RNA expression pattern
File:PBB GE PROX1 207401 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Prospero-related homeobox 1, also known as PROX1, is a human gene.

Further reading

• Zinovieva RD, Duncan MK, Johnson TR; et al. (1996). "Structure and chromosomal localization of the human homeobox gene Prox 1". Genomics. 35 (3): 517–22. doi:10.1006/geno.1996.0392. PMID 8812486.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wigle JT, Chowdhury K, Gruss P, Oliver G (1999). "Prox1 function is crucial for mouse lens-fibre elongation". Nat. Genet. 21 (3): 318–22. doi:10.1038/6844. PMID 10080188.CS1 maint: Multiple names: authors list (link)
• Mouta Carreira C, Nasser SM, di Tomaso E; et al. (2001). "LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis". Cancer Res. 61 (22): 8079–84. PMID 11719431.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rodriguez-Niedenführ M, Papoutsi M, Christ B; et al. (2002). "Prox1 is a marker of ectodermal placodes, endodermal compartments, lymphatic endothelium and lymphangioblasts". Anat. Embryol. 204 (5): 399–406. PMID 11789987.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Duncan MK, Cui W, Oh DJ, Tomarev SI (2002). "Prox1 is differentially localized during lens development". Mech. Dev. 112 (1–2): 195–8. PMID 11850194.CS1 maint: Multiple names: authors list (link)
• Chen Q, Dowhan DH, Liang D; et al. (2002). "CREB-binding protein/p300 co-activation of crystallin gene expression". J. Biol. Chem. 277 (27): 24081–9. doi:10.1074/jbc.M201821200. PMID 11943779.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wilting J, Papoutsi M, Christ B; et al. (2002). "The transcription factor Prox1 is a marker for lymphatic endothelial cells in normal and diseased human tissues". FASEB J. 16 (10): 1271–3. doi:10.1096/fj.01-1010fje. PMID 12060670.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Petrova TV, Mäkinen T, Mäkelä TP; et al. (2002). "Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor". EMBO J. 21 (17): 4593–9. PMID 12198161.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hong YK, Harvey N, Noh YH; et al. (2003). "Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate". Dev. Dyn. 225 (3): 351–7. doi:10.1002/dvdy.10163. PMID 12412020.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dyer MA, Livesey FJ, Cepko CL, Oliver G (2003). "Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina". Nat. Genet. 34 (1): 53–8. doi:10.1038/ng1144. PMID 12692551.CS1 maint: Multiple names: authors list (link)
• Nagai H, Li Y, Hatano S; et al. (2003). "Mutations and aberrant DNA methylation of the PROX1 gene in hematologic malignancies". Genes Chromosomes Cancer. 38 (1): 13–21. doi:10.1002/gcc.10248. PMID 12874782.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Steffensen KR, Holter E, Båvner A; et al. (2005). "Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologue". EMBO Rep. 5 (6): 613–9. doi:10.1038/sj.embor.7400147. PMID 15143342.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Qin J, Gao DM, Jiang QF; et al. (2005). "Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene". Mol. Endocrinol. 18 (10): 2424–39. doi:10.1210/me.2004-0009. PMID 15205472.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dudas J, Papoutsi M, Hecht M; et al. (2005). "The homeobox transcription factor Prox1 is highly conserved in embryonic hepatoblasts and in adult and transformed hepatocytes, but is absent from bile duct epithelium". Anat. Embryol. 208 (5): 359–66. doi:10.1007/s00429-004-0403-4. PMID 15232737.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Reis RM, Reis-Filho JS, Longatto Filho A; et al. (2006). "Differential Prox-1 and CD 31 expression in mucousae, cutaneous and soft tissue vascular lesions and tumors". Pathol. Res. Pract. 201 (12): 771–6. doi:10.1016/j.prp.2005.08.010. PMID 16308102.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Song KH, Li T, Chiang JY (2006). "A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene". J. Biol. Chem. 281 (15): 10081–8. doi:10.1074/jbc.M513420200. PMID 16488887.CS1 maint: Multiple names: authors list (link)
• Schneider M, Büchler P, Giese N; et al. (2006). "Role of lymphangiogenesis and lymphangiogenic factors during pancreatic cancer progression and lymphatic spread". Int. J. Oncol. 28 (4): 883–90. PMID 16525637.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shimoda M, Takahashi M, Yoshimoto T; et al. (2006). "A homeobox protein, prox1, is involved in the differentiation, proliferation, and prognosis in hepatocellular carcinoma". Clin. Cancer Res. 12 (20 Pt 1): 6005–11. doi:10.1158/1078-0432.CCR-06-0712. PMID 17062673.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Laerm A, Helmbold P, Goldberg M; et al. (2007). "Prospero-related homeobox 1 (PROX1) is frequently inactivated by genomic deletions and epigenetic silencing in carcinomas of the bilary system". J. Hepatol. 46 (1): 89–97. doi:10.1016/j.jhep.2006.07.033. PMID 17069925.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• PROX1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.