MNDA

Myeloid cell nuclear differentiation antigen
File:PBB Protein MNDA image.jpg PDB rendering based on 2dbg.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2dbg​
Identifiers
Symbols	MNDA ; PYHIN3
External IDs	Template:OMIM5 HomoloGene: 74438
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MNDA 204959 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Myeloid cell nuclear differentiation antigen, also known as MNDA, is a human gene.

The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.

Further reading

• Burrus GR, Briggs JA, Briggs RC (1992). "Characterization of the human myeloid cell nuclear differentiation antigen: relationship to interferon-inducible proteins". J. Cell. Biochem. 48 (2): 190–202. doi:10.1002/jcb.240480210. PMID 1377701.CS1 maint: Multiple names: authors list (link)
• Briggs JA, Burrus GR, Stickney BD, Briggs RC (1992). "Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha". J. Cell. Biochem. 49 (1): 82–92. doi:10.1002/jcb.240490114. PMID 1644857.CS1 maint: Multiple names: authors list (link)
• Ott J, Fràter-Schröder M (1982). "Absence of linkage between transcobalamin II and ABO". Hum. Genet. 59 (2): 164–5. PMID 7327575.
• Briggs RC, Briggs JA, Ozer J; et al. (1994). "The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located on chromosome 1q that are expressed specifically in hematopoietic cells". Blood. 83 (8): 2153–62. PMID 7512843.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dawson MJ, Trapani JA, Briggs RC; et al. (1995). "The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression". Immunogenetics. 41 (1): 40–3. PMID 7806273.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Briggs R, Dworkin L, Briggs J; et al. (1994). "Interferon alpha selectively affects expression of the human myeloid cell nuclear differentiation antigen in late stage cells in the monocytic but not the granulocytic lineage". J. Cell. Biochem. 54 (2): 198–206. doi:10.1002/jcb.240540208. PMID 8175894.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xie J, Briggs JA, Briggs RC (1998). "Human hematopoietic cell specific nuclear protein MNDA interacts with the multifunctional transcription factor YY1 and stimulates YY1 DNA binding". J. Cell. Biochem. 70 (4): 489–506. PMID 9712147.CS1 maint: Multiple names: authors list (link)
• Doggett KL, Briggs JA, Linton MF; et al. (2002). "Retroviral mediated expression of the human myeloid nuclear antigen in a null cell line upregulates Dlk1 expression". J. Cell. Biochem. 86 (1): 56–66. doi:10.1002/jcb.10190. PMID 12112016.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fukushi M, Higuchi M, Oie M; et al. (2004). "Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts with human myeloid cell nuclear differentiation antigen induced by interferon alpha". Virus Genes. 27 (3): 237–47. PMID 14618084.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Briggs RC, Atkinson JB, Miranda RN (2005). "Variable expression of human myeloid specific nuclear antigen MNDA in monocyte lineage cells in atherosclerosis". J. Cell. Biochem. 95 (2): 293–301. doi:10.1002/jcb.20435. PMID 15778972.CS1 maint: Multiple names: authors list (link)
• Asefa B, Dermott JM, Kaldis P; et al. (2006). "p205, a potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation". FEBS Lett. 580 (5): 1205–14. doi:10.1016/j.febslet.2006.01.032. PMID 16458891.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Briggs RC, Shults KE, Flye LA; et al. (2006). "Dysregulated human myeloid nuclear differentiation antigen expression in myelodysplastic syndromes: evidence for a role in apoptosis". Cancer Res. 66 (9): 4645–51. doi:10.1158/0008-5472.CAN-06-0229. PMID 16651415.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• MNDA+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.