E2F2
| E2F transcription factor 2 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | E2F2 ; E2F-2 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 48264 | ||||||||||
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| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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E2F transcription factor 2, also known as E2F2, is a human gene.
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.[1]
See also
References
Further reading
- Dyson N (1998). "The regulation of E2F by pRB-family proteins". Genes Dev. 12 (15): 2245–62. PMID 9694791.
- Wu CL, Zukerberg LR, Ngwu C; et al. (1995). "In vivo association of E2F and DP family proteins". Mol. Cell. Biol. 15 (5): 2536–46. PMID 7739537.
- Ivey-Hoyle M, Conroy R, Huber HE; et al. (1994). "Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F". Mol. Cell. Biol. 13 (12): 7802–12. PMID 8246995.
- Lees JA, Saito M, Vidal M; et al. (1994). "The retinoblastoma protein binds to a family of E2F transcription factors". Mol. Cell. Biol. 13 (12): 7813–25. PMID 8246996.
- Karlseder J, Rotheneder H, Wintersberger E (1996). "Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F". Mol. Cell. Biol. 16 (4): 1659–67. PMID 8657141.
- Lin SY, Black AR, Kostic D; et al. (1996). "Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction". Mol. Cell. Biol. 16 (4): 1668–75. PMID 8657142.
- Rogers KT, Higgins PD, Milla MM; et al. (1996). "DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 7594–9. PMID 8755520.
- Magae J, Wu CL, Illenye S; et al. (1997). "Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members". J. Cell. Sci. 109 ( Pt 7): 1717–26. PMID 8832394.
- Hofmann F, Livingston DM (1996). "Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit". Genes Dev. 10 (7): 851–61. PMID 8846921.
- Lindeman GJ, Gaubatz S, Livingston DM, Ginsberg D (1997). "The subcellular localization of E2F-4 is cell-cycle dependent". Proc. Natl. Acad. Sci. U.S.A. 94 (10): 5095–100. PMID 9144196.
- Pierce AM, Schneider-Broussard R, Philhower JL, Johnson DG (1998). "Differential activities of E2F family members: unique functions in regulating transcription". Mol. Carcinog. 22 (3): 190–8. PMID 9688145.
- Halaban R, Cheng E, Smicun Y, Germino J (2000). "Deregulated E2F transcriptional activity in autonomously growing melanoma cells". J. Exp. Med. 191 (6): 1005–16. PMID 10727462.
- Takahashi Y, Rayman JB, Dynlacht BD (2000). "Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression". Genes Dev. 14 (7): 804–16. PMID 10766737.
- Denis GV, Vaziri C, Guo N, Faller DV (2001). "RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F". Cell Growth Differ. 11 (8): 417–24. PMID 10965846.
- Wu L, Timmers C, Maiti B; et al. (2001). "The E2F1-3 transcription factors are essential for cellular proliferation". Nature. 414 (6862): 457–62. doi:10.1038/35106593. PMID 11719808.
- Yamochi T, Semba K, Tsuji K; et al. (2002). "ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3)". Eur. J. Biochem. 268 (23): 6076–82. PMID 11733001.
- Weinmann AS, Yan PS, Oberley MJ; et al. (2002). "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis". Genes Dev. 16 (2): 235–44. doi:10.1101/gad.943102. PMID 11799066.
- Crowley TE, Kaine EM, Yoshida M; et al. (2003). "Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein". Mol. Endocrinol. 16 (8): 1727–37. PMID 12145330.
- Schlisio S, Halperin T, Vidal M, Nevins JR (2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". EMBO J. 21 (21): 5775–86. PMID 12411495.
External links
- E2F2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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