POU4F2
| POU domain, class 4, transcription factor 2 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | POU4F2 ; BRN3.2; BRN3B; Brn-3b | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 20959 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE POU4F2 207725 at tn.png | |||||||||||
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| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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POU domain, class 4, transcription factor 2, also known as POU4F2, is a human gene.[1]
POU4F2 is a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. A class IV POU-domain protein, POU4F2 is found in human retina exclusively within a subpopulation of ganglion cells where it may play a role in determining or maintaining the identities of a small subset of visual system neurons.[supplied by OMIM][1]
See also
References
Further reading
- Xiang M, Zhou L, Macke JP; et al. (1995). "The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons". J. Neurosci. 15 (7 Pt 1): 4762–85. PMID 7623109.
- Xiang M, Zhou L, Peng YW; et al. (1993). "Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells". Neuron. 11 (4): 689–701. PMID 7691107.
- Bhargava AK, Li Z, Weissman SM (1993). "Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells". Proc. Natl. Acad. Sci. U.S.A. 90 (21): 10260–4. PMID 8234287.
- Ring CJ, Latchman DS (1993). "The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain". Nucleic Acids Res. 21 (12): 2946. PMID 8332509.
- Smith MD, Dawson SJ, Latchman DS (1997). "Inhibition of neuronal process outgrowth and neuronal specific gene activation by the Brn-3b transcription factor". J. Biol. Chem. 272 (2): 1382–8. PMID 8995448.
- Budhram-Mahadeo V, Parker M, Latchman DS (1998). "POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element". Mol. Cell. Biol. 18 (2): 1029–41. PMID 9448000.
- Dennis JH, Budhram-Mahadeo V, Latchman DS (2001). "The Brn-3b POU family transcription factor regulates the cellular growth, proliferation, and anchorage dependence of MCF7 human breast cancer cells". Oncogene. 20 (36): 4961–71. doi:10.1038/sj.onc.1204491. PMID 11526481.
- de Melo J, Qiu X, Du G; et al. (2003). "Dlx1, Dlx2, Pax6, Brn3b, and Chx10 homeobox gene expression defines the retinal ganglion and inner nuclear layers of the developing and adult mouse retina". J. Comp. Neurol. 461 (2): 187–204. doi:10.1002/cne.10674. PMID 12724837.
- Samady L, Dennis J, Budhram-Mahadeo V, Latchman DS (2004). "Activation of CDK4 gene expression in human breast cancer cells by the Brn-3b POU family transcription factor". Cancer Biol. Ther. 3 (3): 317–23. PMID 14726699.
- Irshad S, Pedley RB, Anderson J; et al. (2004). "The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo". J. Biol. Chem. 279 (20): 21617–27. doi:10.1074/jbc.M312506200. PMID 14970234.
- Lee SA, Ndisang D, Patel C; et al. (2005). "Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter". Cancer Res. 65 (8): 3072–80. doi:10.1158/0008-5472.CAN-04-2865. PMID 15833836.
- Weishaupt JH, Klöcker N, Bähr M (2005). "Axotomy-induced early down-regulation of POU-IV class transcription factors Brn-3a and Brn-3b in retinal ganglion cells". J. Mol. Neurosci. 26 (1): 17–25. PMID 15968082.
- Samady L, Faulkes DJ, Budhram-Mahadeo V; et al. (2006). "The Brn-3b POU family transcription factor represses plakoglobin gene expression in human breast cancer cells". Int. J. Cancer. 118 (4): 869–78. doi:10.1002/ijc.21435. PMID 16152597.
- Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
- Choy KW, Wang CC, Ogura A; et al. (2007). "Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes". Physiol. Genomics. 25 (1): 9–15. doi:10.1152/physiolgenomics.00121.2005. PMID 16368877.
- Calissano M, Diss JK, Latchman DS (2007). "Post-transcriptional regulation of the Brn-3b transcription factor in differentiating neuroblastoma cells". FEBS Lett. 581 (13): 2490–6. doi:10.1016/j.febslet.2007.04.066. PMID 17490655.
External links
- POU4F2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.