KLF6

Kruppel-like factor 6
Identifiers
Symbols	KLF6 ; BCD1; COPEB; CPBP; DKFZp686N0199; GBF; PAC1; ST12; ZF9
External IDs	Template:OMIM5 Template:MGI HomoloGene: 996
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE KLF6 208961 s at tn.png
File:PBB GE KLF6 208960 s at tn.png
File:PBB GE KLF6 211610 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Kruppel-like factor 6, also known as KLF6, is a human gene.

This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an important role in the process of transcriptional activation. It is capable of activating transcription approximately 4-fold either on homologous or heterologous promoters. The DNA binding and transcriptional activity of this protein, in conjunction with its expression pattern, suggests that this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes. Two transcript variants encoding the same protein have been found for this gene.

See also

• Kruppel-like factors

Further reading

• Narla G, Friedman SL, Martignetti JA (2003). "Krüppel cripples prostate cancer: KLF6 progress and prospects". Am. J. Pathol. 162 (4): 1047–52. PMID 12651597.CS1 maint: Multiple names: authors list (link)
• El Rouby S, Newcomb EW (1997). "Identification of Bcd, a novel proto-oncogene expressed in B-cells". Oncogene. 13 (12): 2623–30. PMID 9000136.
• Koritschoner NP, Bocco JL, Panzetta-Dutari GM; et al. (1997). "A novel human zinc finger protein that interacts with the core promoter element of a TATA box-less gene". J. Biol. Chem. 272 (14): 9573–80. PMID 9083102.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Onyango P, Koritschoner NP, Patrito LC; et al. (1998). "Assignment of the gene encoding the core promoter element binding protein (COPEB) to human chromosome 10p15 by somatic hybrid analysis and fluorescence in situ hybridization". Genomics. 48 (1): 143–4. doi:10.1006/geno.1997.5124. PMID 9503030.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki T, Yamamoto T, Kurabayashi M; et al. (1998). "Isolation and initial characterization of GBF, a novel DNA-binding zinc finger protein that binds to the GC-rich binding sites of the HIV-1 promoter". J. Biochem. 124 (2): 389–95. PMID 9685731.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ratziu V, Lalazar A, Wong L; et al. (1998). "Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis". Proc. Natl. Acad. Sci. U.S.A. 95 (16): 9500–5. PMID 9689109.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Okano J, Opitz OG, Nakagawa H; et al. (2000). "The Krüppel-like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interact". FEBS Lett. 473 (1): 95–100. PMID 10802067.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Narla G, Heath KE, Reeves HL; et al. (2002). "KLF6, a candidate tumor suppressor gene mutated in prostate cancer". Science. 294 (5551): 2563–6. doi:10.1126/science.1066326. PMID 11752579.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Botella LM, Sánchez-Elsner T, Sanz-Rodriguez F; et al. (2003). "Transcriptional activation of endoglin and transforming growth factor-beta signaling components by cooperative interaction between Sp1 and KLF6: their potential role in the response to vascular injury". Blood. 100 (12): 4001–10. doi:10.1182/blood.V100.12.4001. PMID 12433697.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen HK, Liu XQ, Lin J; et al. (2003). "[Mutation analysis of KLF6 gene in human nasopharyngeal carcinomas]". Ai Zheng. 21 (10): 1047–50. PMID 12508640.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Warke VG, Nambiar MP, Krishnan S; et al. (2003). "Transcriptional activation of the human inducible nitric-oxide synthase promoter by Kruppel-like factor 6". J. Biol. Chem. 278 (17): 14812–9. doi:10.1074/jbc.M300787200. PMID 12590140.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen C, Hyytinen ER, Sun X; et al. (2003). "Deletion, mutation, and loss of expression of KLF6 in human prostate cancer". Am. J. Pathol. 162 (4): 1349–54. PMID 12651626.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jeng YM, Hsu HC (2003). "KLF6, a putative tumor suppressor gene, is mutated in astrocytic gliomas". Int. J. Cancer. 105 (5): 625–9. doi:10.1002/ijc.11123. PMID 12740910.
• Bayat A, Watson JS, Stanley JK; et al. (2003). "Genetic susceptibility to dupuytren disease: association of Zf9 transcription factor gene". Plast. Reconstr. Surg. 111 (7): 2133–9. doi:10.1097/01.PRS.0000060531.98180.32. PMID 12794452.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Reeves HL, Narla G, Ogunbiyi O; et al. (2004). "Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer". Gastroenterology. 126 (4): 1090–103. PMID 15057748.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimmelman AC, Qiao RF, Narla G; et al. (2004). "Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6". Oncogene. 23 (29): 5077–83. doi:10.1038/sj.onc.1207662. PMID 15064720.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Glinsky GV, Glinskii AB, Stephenson AJ; et al. (2004). "Gene expression profiling predicts clinical outcome of prostate cancer". J. Clin. Invest. 113 (6): 913–23. doi:10.1172/JCI200420032. PMID 15067324.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rubinstein M, Idelman G, Plymate SR; et al. (2004). "Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53". Endocrinology. 145 (8): 3769–77. doi:10.1210/en.2004-0173. PMID 15131018.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• KLF6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.