SOX6

SRY (sex determining region Y)-box 6
File:PBB Protein SOX6 image.jpg PDB rendering based on 1i11.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1i11​
Identifiers
Symbols	SOX6 ; HSSOX6
External IDs	Template:OMIM5 Template:MGI HomoloGene: 22631
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

SRY (sex determining region Y)-box 6, also known as SOX6, is a human gene.

The SOX gene family encodes a group of transcription factors defined by the conserved high mobility group (HMG) DNA-binding domain. Unlike most transcription factors, SOX transcription factors bind to the minor groove of DNA, causing a 70- to 85-degree bend and introducing local conformational changes.[supplied by OMIM]

See also

• SOX genes

Further reading

• Denny P, Swift S, Brand N; et al. (1992). "A conserved family of genes related to the testis determining gene, SRY". Nucleic Acids Res. 20 (11): 2887. PMID 1614875.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lefebvre V, Li P, de Crombrugghe B (1998). "A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene". EMBO J. 17 (19): 5718–33. doi:10.1093/emboj/17.19.5718. PMID 9755172.CS1 maint: Multiple names: authors list (link)
• Hagiwara N, Klewer SE, Samson RA; et al. (2000). "Sox6 is a candidate gene for p100H myopathy, heart block, and sudden neonatal death". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 4180–5. PMID 10760285.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamashita A, Ito M, Takamatsu N, Shiba T (2000). "Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis". FEBS Lett. 481 (2): 147–51. PMID 10996314.CS1 maint: Multiple names: authors list (link)
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.CS1 maint: Multiple names: authors list (link)
• Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cohen-Barak O, Hagiwara N, Arlt MF; et al. (2001). "Cloning, characterization and chromosome mapping of the human SOX6 gene". Gene. 265 (1–2): 157–64. PMID 11255018.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Murakami A, Ishida S, Thurlow J; et al. (2001). "SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter". Nucleic Acids Res. 29 (16): 3347–55. PMID 11504872.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cohen-Barak O, Yi Z, Hagiwara N; et al. (2004). "Sox6 regulation of cardiac myocyte development". Nucleic Acids Res. 31 (20): 5941–8. PMID 14530442.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ueda R, Yoshida K, Kawakami Y; et al. (2005). "Expression of a transcriptional factor, SOX6, in human gliomas". Brain tumor pathology. 21 (1): 35–8. PMID 15696967.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ueda R, Yoshida K, Kawakami Y; et al. (2005). "Immunohistochemical analysis of SOX6 expression in human brain tumors". Brain tumor pathology. 21 (3): 117–20. PMID 15696972.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mehrle A, Rosenfelder H, Schupp I; et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fernández-Lloris R, Osses N, Jaffray E; et al. (2006). "Repression of SOX6 transcriptional activity by SUMO modification". FEBS Lett. 580 (5): 1215–21. doi:10.1016/j.febslet.2006.01.031. PMID 16442531.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ikeda T, Saito T, Ushita M; et al. (2007). "Identification and characterization of the human SOX6 promoter". Biochem. Biophys. Res. Commun. 357 (2): 383–90. doi:10.1016/j.bbrc.2007.03.133. PMID 17433257.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• SOX6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.