ARID4A

AT rich interactive domain 4A (RBP1-like)
Identifiers
Symbols	ARID4A ; RBBP1; RBP-1; RBP1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 11303
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

AT rich interactive domain 4A (RBP1-like), also known as ARID4A, is a human gene.

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described.

Further reading

• Defeo-Jones D, Huang PS, Jones RE; et al. (1991). "Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product". Nature. 352 (6332): 251–4. doi:10.1038/352251a0. PMID 1857421.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fattaey AR, Helin K, Dembski MS; et al. (1993). "Characterization of the retinoblastoma binding proteins RBP1 and RBP2". Oncogene. 8 (11): 3149–56. PMID 8414517.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Otterson GA, Kratzke RA, Lin AY; et al. (1993). "Alternative splicing of the RBP1 gene clusters in an internal exon that encodes potential phosphorylation sites". Oncogene. 8 (4): 949–57. PMID 8455946.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Margottin F, Bour SP, Durand H; et al. (1998). "A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif". Mol. Cell. 1 (4): 565–74. PMID 9660940.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lai A, Marcellus RC, Corbeil HB, Branton PE (1999). "RBP1 induces growth arrest by repression of E2F-dependent transcription". Oncogene. 18 (12): 2091–100. doi:10.1038/sj.onc.1202520. PMID 10321733.CS1 maint: Multiple names: authors list (link)
• Cao J, Gao T, Giuliano AE, Irie RF (1999). "Recognition of an epitope of a breast cancer antigen by human antibody". Breast Cancer Res. Treat. 53 (3): 279–90. PMID 10369074.CS1 maint: Multiple names: authors list (link)
• Lai A, Lee JM, Yang WM; et al. (2000). "RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins". Mol. Cell. Biol. 19 (10): 6632–41. PMID 10490602.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lai A, Kennedy BK, Barbie DA; et al. (2001). "RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest". Mol. Cell. Biol. 21 (8): 2918–32. doi:10.1128/MCB.21.8.2918-2932.2001. PMID 11283269.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fleischer TC, Yun UJ, Ayer DE (2003). "Identification and characterization of three new components of the mSin3A corepressor complex". Mol. Cell. Biol. 23 (10): 3456–67. PMID 12724404.CS1 maint: Multiple names: authors list (link)
• Meehan WJ, Samant RS, Hopper JE; et al. (2004). "Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription". J. Biol. Chem. 279 (2): 1562–9. doi:10.1074/jbc.M307969200. PMID 14581478.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Monroe DG, Secreto FJ, Hawse JR; et al. (2006). "Estrogen receptor isoform-specific regulation of the retinoblastoma-binding protein 1 (RBBP1) gene: roles of AF1 and enhancer elements". J. Biol. Chem. 281 (39): 28596–604. doi:10.1074/jbc.M605226200. PMID 16873370.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• ARID4A+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.