NFATC3
| Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | NFATC3 ; NFAT4; NFATX | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 27827 | ||||||||||
| |||||||||||
| RNA expression pattern | |||||||||||
| File:PBB GE NFATC3 210555 s at tn.png | |||||||||||
| File:PBB GE NFATC3 207416 s at tn.png | |||||||||||
| File:PBB GE NFATC3 210556 at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3, also known as NFATC3, is a human gene.[1]
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Four transcript variants encoding distinct isoforms have been identified for this gene.[1]
See also
References
Further reading
- Rao A, Luo C, Hogan PG (1997). "Transcription factors of the NFAT family: regulation and function". Annu. Rev. Immunol. 15: 707–47. doi:10.1146/annurev.immunol.15.1.707. PMID 9143705.
- Crabtree GR (1999). "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT". Cell. 96 (5): 611–4. PMID 10089876.
- Horsley V, Pavlath GK (2002). "NFAT: ubiquitous regulator of cell differentiation and adaptation". J. Cell Biol. 156 (5): 771–4. doi:10.1083/jcb.200111073. PMID 11877454.
- Masuda ES, Naito Y, Tokumitsu H; et al. (1995). "NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus". Mol. Cell. Biol. 15 (5): 2697–706. PMID 7739550.
- Hoey T, Sun YL, Williamson K, Xu X (1995). "Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins". Immunity. 2 (5): 461–72. PMID 7749981.
- Jabado N, Le Deist F, Fisher A, Hivroz C (1994). "Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity". Eur. J. Immunol. 24 (11): 2646–52. PMID 7957556.
- Vacca A, Farina M, Maroder M; et al. (1995). "Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif". Biochem. Biophys. Res. Commun. 205 (1): 467–74. doi:10.1006/bbrc.1994.2689. PMID 7999066.
- Di Somma MM, Majolini MB, Burastero SE; et al. (1996). "Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering". Eur. J. Immunol. 26 (9): 2181–8. PMID 8814265.
- Masuda ES, Liu J, Imamura R; et al. (1997). "Control of NFATx1 nuclear translocation by a calcineurin-regulated inhibitory domain". Mol. Cell. Biol. 17 (4): 2066–75. PMID 9121455.
- Chow CW, Rincón M, Cavanagh J; et al. (1997). "Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway". Science. 278 (5343): 1638–41. PMID 9374467.
- Amasaki Y, Masuda ES, Imamura R; et al. (1998). "Distinct NFAT family proteins are involved in the nuclear NFAT-DNA binding complexes from human thymocyte subsets". J. Immunol. 160 (5): 2324–33. PMID 9498773.
- Zhu J, Shibasaki F, Price R; et al. (1998). "Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1". Cell. 93 (5): 851–61. PMID 9630228.
- Aramburu J, Garcia-Cózar F, Raghavan A; et al. (1998). "Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT". Mol. Cell. 1 (5): 627–37. PMID 9660947.
- Imamura R, Masuda ES, Naito Y; et al. (1998). "Carboxyl-terminal 15-amino acid sequence of NFATx1 is possibly created by tissue-specific splicing and is essential for transactivation activity in T cells". J. Immunol. 161 (7): 3455–63. PMID 9759864.
- Loftus BJ, Kim UJ, Sneddon VP; et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
- Amasaki Y, Adachi S, Ishida Y; et al. (2002). "A constitutively nuclear form of NFATx shows efficient transactivation activity and induces differentiation of CD4(+)CD8(+) T cells". J. Biol. Chem. 277 (28): 25640–8. doi:10.1074/jbc.M201860200. PMID 11997392.
- Chagnon P, Michaud J, Mitchell G; et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis". Am. J. Hum. Genet. 71 (6): 1443–9. PMID 12417987.
External links
- NFATC3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 | This protein-related article is a stub. You can help Wikipedia by expanding it. |