NFAT5

Nuclear factor of activated T-cells 5, tonicity-responsive
File:PBB Protein NFAT5 image.jpg PDB rendering based on 1imh.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1imh​
Identifiers
Symbols	NFAT5 ; KIAA0827; NF-AT5; NFATL1; NFATZ; OREBP; TONEBP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4811
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE NFAT5 208003 s at tn.png
File:PBB GE NFAT5 215092 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Nuclear factor of activated T-cells 5, tonicity-responsive, also known as NFAT5, is a human gene.

The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene.

See also

• NFAT

Further reading

• López-Rodríguez C, Aramburu J, Rakeman AS; et al. (2001). "NF-AT5: the NF-AT family of transcription factors expands in a new direction". Cold Spring Harb. Symp. Quant. Biol. 64: 517–26. PMID 11233530.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Horsley V, Pavlath GK (2002). "NFAT: ubiquitous regulator of cell differentiation and adaptation". J. Cell Biol. 156 (5): 771–4. doi:10.1083/jcb.200111073. PMID 11877454.
• Nagase T, Ishikawa K, Suyama M; et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. PMID 10048485.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miyakawa H, Woo SK, Dahl SC; et al. (1999). "Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2538–42. PMID 10051678.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lopez-Rodríguez C, Aramburu J, Rakeman AS, Rao A (1999). "NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun". Proc. Natl. Acad. Sci. U.S.A. 96 (13): 7214–9. PMID 10377394.CS1 maint: Multiple names: authors list (link)
• Zühlke C, Kiehl R, Johannsmeyer A; et al. (2000). "Isolation and characterization of novel CAG repeat containing genes expressed in human brain". DNA Seq. 10 (1): 1–6. PMID 10565538.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ko BC, Turck CW, Lee KW; et al. (2000). "Purification, identification, and characterization of an osmotic response element binding protein". Biochem. Biophys. Res. Commun. 270 (1): 52–61. doi:10.1006/bbrc.2000.2376. PMID 10733904.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Trama J, Lu Q, Hawley RG, Ho SN (2000). "The NFAT-related protein NFATL1 (TonEBP/NFAT5) is induced upon T cell activation in a calcineurin-dependent manner". J. Immunol. 165 (9): 4884–94. PMID 11046013.CS1 maint: Multiple names: authors list (link)
• Hebinck A, Dalski A, Engel H; et al. (2000). "Assignment of transcription factor NFAT5 to human chromosome 16q22.1, murine chromosome 8D and porcine chromosome 6p1.4 and comparison of the polyglutamine domains". Cytogenet. Cell Genet. 90 (1–2): 68–70. PMID 11060450.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• López-Rodríguez C, Aramburu J, Jin L; et al. (2001). "Bridging the NFAT and NF-kappaB families: NFAT5 dimerization regulates cytokine gene transcription in response to osmotic stress". Immunity. 15 (1): 47–58. PMID 11485737.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dalski A, Schwinger E, Zühlke C (2001). "Genomic organization of the human NFAT5 gene: exon-intron structure of the 14-kb transcript and CpG-island analysis of the promoter region". Cytogenet. Cell Genet. 93 (3–4): 239–41. PMID 11528118.CS1 maint: Multiple names: authors list (link)
• Stroud JC, Lopez-Rodriguez C, Rao A, Chen L (2002). "Structure of a TonEBP-DNA complex reveals DNA encircled by a transcription factor". Nat. Struct. Biol. 9 (2): 90–4. doi:10.1038/nsb749. PMID 11780147.CS1 maint: Multiple names: authors list (link)
• Ferraris JD, Williams CK, Persaud P; et al. (2002). "Activity of the TonEBP/OREBP transactivation domain varies directly with extracellular NaCl concentration". Proc. Natl. Acad. Sci. U.S.A. 99 (2): 739–44. doi:10.1073/pnas.241637298. PMID 11792870.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Merante F, Altamentova SM, Mickle DA; et al. (2002). "The characterization and purification of a human transcription factor modulating the glutathione peroxidase gene in response to oxygen tension". Mol. Cell. Biochem. 229 (1–2): 73–83. PMID 11936849.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jauliac S, López-Rodriguez C, Shaw LM; et al. (2002). "The role of NFAT transcription factors in integrin-mediated carcinoma invasion". Nat. Cell Biol. 4 (7): 540–4. doi:10.1038/ncb816. PMID 12080349.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ko BC, Lam AK, Kapus A; et al. (2003). "Fyn and p38 signaling are both required for maximal hypertonic activation of the osmotic response element-binding protein/tonicity-responsive enhancer-binding protein (OREBP/TonEBP)". J. Biol. Chem. 277 (48): 46085–92. doi:10.1074/jbc.M208138200. PMID 12359721.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kneitz C, Goller M, Tony H; et al. (2002). "The CD23b promoter is a target for NF-AT transcription factors in B-CLL cells". Biochim. Biophys. Acta. 1588 (1): 41–7. PMID 12379312.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMID 12421765.CS1 maint: Multiple names: authors list (link)

External links

• NFAT5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.