IRF8

Interferon regulatory factor 8
Identifiers
Symbols	IRF8 ; H-ICSBP; ICSBP; ICSBP1; IRF-8
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1629
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Interferon regulatory factor 8, also known as IRF8, is a human gene.

Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection.

See also

• Interferon regulatory factors

Further reading

• Weisz A, Marx P, Sharf R; et al. (1993). "Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes". J. Biol. Chem. 267 (35): 25589–96. PMID 1460054.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sharf R, Azriel A, Lejbkowicz F; et al. (1995). "Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factors". J. Biol. Chem. 270 (22): 13063–9. PMID 7768900.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Holtschke T, Löhler J, Kanno Y; et al. (1996). "Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene". Cell. 87 (2): 307–17. PMID 8861914.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schaper F, Kirchhoff S, Posern G; et al. (1998). "Functional domains of interferon regulatory factor I (IRF-1)". Biochem. J. 335 ( Pt 1): 147–57. PMID 9742224.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li W, Nagineni CN, Ge H; et al. (1999). "Interferon consensus sequence-binding protein is constitutively expressed and differentially regulated in the ocular lens". J. Biol. Chem. 274 (14): 9686–91. PMID 10092656.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li W, Nagineni CN, Hooks JJ; et al. (1999). "Interferon-gamma signaling in human retinal pigment epithelial cells mediated by STAT1, ICSBP, and IRF-1 transcription factors". Invest. Ophthalmol. Vis. Sci. 40 (5): 976–82. PMID 10102295.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rehli M, Poltorak A, Schwarzfischer L; et al. (2000). "PU.1 and interferon consensus sequence-binding protein regulate the myeloid expression of the human Toll-like receptor 4 gene". J. Biol. Chem. 275 (13): 9773–81. PMID 10734131.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cohen H, Azriel A, Cohen T; et al. (2001). "Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome". J. Biol. Chem. 275 (50): 39081–9. doi:10.1074/jbc.M004900200. PMID 10991940.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nehyba J, Hrdlicková R, Burnside J, Bose HR (2002). "A novel interferon regulatory factor (IRF), IRF-10, has a unique role in immune defense and is induced by the v-Rel oncoprotein". Mol. Cell. Biol. 22 (11): 3942–57. PMID 11997525.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhu C, Saberwal G, Lu Y; et al. (2005). "The interferon consensus sequence-binding protein activates transcription of the gene encoding neurofibromin 1". J. Biol. Chem. 279 (49): 50874–85. doi:10.1074/jbc.M405736200. PMID 15371411.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu J, Guan X, Tamura T; et al. (2005). "Synergistic activation of interleukin-12 p35 gene transcription by interferon regulatory factor-1 and interferon consensus sequence-binding protein". J. Biol. Chem. 279 (53): 55609–17. doi:10.1074/jbc.M406565200. PMID 15489234.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Barrios-Rodiles M, Brown KR, Ozdamar B; et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xiong H, Li H, Kong HJ; et al. (2005). "Ubiquitin-dependent degradation of interferon regulatory factor-8 mediated by Cbl down-regulates interleukin-12 expression". J. Biol. Chem. 280 (25): 23531–9. doi:10.1074/jbc.M414296200. PMID 15837792.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhao J, Kong HJ, Li H; et al. (2006). "IRF-8/interferon (IFN) consensus sequence-binding protein is involved in Toll-like receptor (TLR) signaling and contributes to the cross-talk between TLR and IFN-gamma signaling pathways". J. Biol. Chem. 281 (15): 10073–80. doi:10.1074/jbc.M507788200. PMID 16484229.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Huang W, Saberwal G, Horvath E; et al. (2006). "Leukemia-associated, constitutively active mutants of SHP2 protein tyrosine phosphatase inhibit NF1 transcriptional activation by the interferon consensus sequence binding protein". Mol. Cell. Biol. 26 (17): 6311–32. doi:10.1128/MCB.00036-06. PMID 16914719.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dimberg A, Kårehed K, Nilsson K, Oberg F (2006). "Inhibition of monocytic differentiation by phosphorylation-deficient Stat1 is associated with impaired expression of Stat2, ICSBP/IRF8 and C/EBPepsilon". Scand. J. Immunol. 64 (3): 271–9. doi:10.1111/j.1365-3083.2006.01827.x. PMID 16918696.CS1 maint: Multiple names: authors list (link)
• Peng YB, Yerle M, Liu B (2007). "Mapping of nine porcine interferon regulatory factor genes". Anim. Genet. 37 (6): 600–1. doi:10.1111/j.1365-2052.2006.01525.x. PMID 17121613.CS1 maint: Multiple names: authors list (link)
• Huang W, Horvath E, Eklund EA (2007). "PU.1, interferon regulatory factor (IRF) 2, and the interferon consensus sequence-binding protein (ICSBP/IRF8) cooperate to activate NF1 transcription in differentiating myeloid cells". J. Biol. Chem. 282 (9): 6629–43. doi:10.1074/jbc.M607760200. PMID 17200120.CS1 maint: Multiple names: authors list (link)

External links

• IRF8+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.