HOXB4
| Homeobox B4 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | HOXB4 ; HOX2; HOX-2.6; HOX2F | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 32095 | ||||||||||
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| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Homeobox B4, also known as HOXB4, is a human gene.[1]
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.[1]
See also
References
Further reading
- Petrini M, Quaranta MT, Testa U; et al. (1992). "Expression of selected human HOX-2 genes in B/T acute lymphoid leukemia and interleukin-2/interleukin-1 beta-stimulated natural killer lymphocytes". Blood. 80 (1): 185–93. PMID 1351762.
- Scott MP (1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. PMID 1358459.
- McAlpine PJ, Shows TB (1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. PMID 1973146.
- Peverali FA, D'Esposito M, Acampora D; et al. (1991). "Expression of HOX homeogenes in human neuroblastoma cell culture lines". Differentiation. 45 (1): 61–9. PMID 1981366.
- Giampaolo A, Acampora D, Zappavigna V; et al. (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation. 40 (3): 191–7. PMID 2570724.
- Acampora D, D'Esposito M, Faiella A; et al. (1990). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402. PMID 2574852.
- Boncinelli E, Acampora D, Pannese M; et al. (1990). "Organization of human class I homeobox genes". Genome. 31 (2): 745–56. PMID 2576652.
- Kuliev A, Kukharenko V, Morozov G; et al. (1996). "Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies". J. Assist. Reprod. Genet. 13 (2): 177–81. PMID 8688592.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.
- Bodey B, Bodey B, Siegel SE, Kaiser HE (2000). "Immunocytochemical detection of the homeobox B3, B4, and C6 gene products within the human thymic cellular microenvironment". In Vivo. 14 (3): 419–24. PMID 10904875.
- Giannola DM, Shlomchik WD, Jegathesan M; et al. (2000). "Hematopoietic expression of HOXB4 is regulated in normal and leukemic stem cells through transcriptional activation of the HOXB4 promoter by upstream stimulating factor (USF)-1 and USF-2". J. Exp. Med. 192 (10): 1479–90. PMID 11085749.
- Pan Q, Simpson RU (2001). "Antisense knockout of HOXB4 blocks 1,25-dihydroxyvitamin D3 inhibition of c-myc expression". J. Endocrinol. 169 (1): 153–9. PMID 11250656.
- Shen WF, Krishnan K, Lawrence HJ, Largman C (2001). "The HOX homeodomain proteins block CBP histone acetyltransferase activity". Mol. Cell. Biol. 21 (21): 7509–22. doi:10.1128/MCB.21.21.7509-7522.2001. PMID 11585930.
- Kömüves LG, Michael E, Arbeit JM; et al. (2002). "HOXB4 homeodomain protein is expressed in developing epidermis and skin disorders and modulates keratinocyte proliferation". Dev. Dyn. 224 (1): 58–68. doi:10.1002/dvdy.10085. PMID 11984874.
- Buske C, Feuring-Buske M, Abramovich C; et al. (2002). "Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells". Blood. 100 (3): 862–8. doi:10.1182/blood-2002-01-0220. PMID 12130496.
- Schiedlmeier B, Klump H, Will E; et al. (2003). "High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation". Blood. 101 (5): 1759–68. doi:10.1182/blood-2002-03-0767. PMID 12406897.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Theokli C, Morsi El-Kadi AS, Morgan R (2004). "TALE class homeodomain gene Irx5 is an immediate downstream target for Hoxb4 transcriptional regulation". Dev. Dyn. 227 (1): 48–55. doi:10.1002/dvdy.10287. PMID 12701098.
- Kömüves LG, Ma XK, Stelnicki E; et al. (2004). "HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development". Dev. Dyn. 227 (2): 192–202. doi:10.1002/dvdy.10290. PMID 12761847.
- Zhu J, Giannola DM, Zhang Y; et al. (2003). "NF-Y cooperates with USF1/2 to induce the hematopoietic expression of HOXB4". Blood. 102 (7): 2420–7. doi:10.1182/blood-2003-01-0251. PMID 12791656.
External links
- HOXB4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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