MNT (gene)

MAX binding protein
Identifiers
Symbols	MNT ; MAD6; MXD6; ROX
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7842
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MNT 204206 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

MAX binding protein, also known as MNT, is a human gene.

The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain.

Further reading

• Meroni G, Reymond A, Alcalay M; et al. (1997). "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor". EMBO J. 16 (10): 2892–906. doi:10.1093/emboj/16.10.2892. PMID 9184233.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hirotsune S, Pack SD, Chong SS; et al. (1997). "Genomic organization of the murine Miller-Dieker/lissencephaly region: conservation of linkage with the human region". Genome Res. 7 (6): 625–34. PMID 9199935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nigro CL, Venesio T, Reymond A; et al. (1998). "The human ROX gene: genomic structure and mutation analysis in human breast tumors". Genomics. 49 (2): 275–82. doi:10.1006/geno.1998.5241. PMID 9598315.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Meroni G, Cairo S, Merla G; et al. (2000). "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene. 19 (29): 3266–77. doi:10.1038/sj.onc.1203634. PMID 10918583.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cairo S, Merla G, Urbinati F; et al. (2001). "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Hum. Mol. Genet. 10 (6): 617–27. PMID 11230181.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stoneley M, Spencer JP, Wright SC (2001). "An internal ribosome entry segment in the 5' untranslated region of the mnt gene". Oncogene. 20 (7): 893–7. doi:10.1038/sj.onc.1204157. PMID 11314024.CS1 maint: Multiple names: authors list (link)
• Dintilhac A, Bernués J (2002). "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences". J. Biol. Chem. 277 (9): 7021–8. doi:10.1074/jbc.M108417200. PMID 11748221.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Smith AG, Popov N, Imreh M; et al. (2005). "Expression and DNA-binding activity of MYCN/Max and Mnt/Max during induced differentiation of human neuroblastoma cells". J. Cell. Biochem. 92 (6): 1282–95. doi:10.1002/jcb.20121. PMID 15258910.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oh JH, Yang JO, Hahn Y; et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guo XL, Pan L, Zhang XJ; et al. (2007). "Expression and mutation analysis of genes that encode the Myc antagonists Mad1, Mxi1 and Rox in acute leukaemia". Leuk. Lymphoma. 48 (6): 1200–7. doi:10.1080/10428190701342018. PMID 17577784.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• MNT+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.