NEUROD2
| Neurogenic differentiation 2 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | NEUROD2 ; MGC26304; NDRF | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 4489 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE NEUROD2 210271 at tn.png | |||||||||||
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| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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Neurogenic differentiation 2, also known as NEUROD2, is a human gene.[1]
This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates.[1]
References
Further reading
- McCormick MB, Tamimi RM, Snider L; et al. (1996). "NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family". Mol. Cell. Biol. 16 (10): 5792–800. PMID 8816493.
- Tamimi RM, Steingrimsson E, Montgomery-Dyer K; et al. (1997). "NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively". Genomics. 40 (2): 355–7. doi:10.1006/geno.1996.4578. PMID 9119405.
- Kume H, Maruyama K, Shinozaki K; et al. (1998). "Phosphorylation and spatiotemporal distribution of KW8 (NDRF/NeuroD2), a NeuroD family basic helix-loop-helix protein". Brain Res. Mol. Brain Res. 60 (1): 107–14. PMID 9748526.
- Kitamura T, Miyachi T, Nakamura S, Kawakami H (1999). "Identification and analysis of the promoter region of the human NeuroD-related factor (NDRF)1". Biochim. Biophys. Acta. 1445 (1): 142–7. PMID 10209266.
- Shibata H, Oda H, Mukai H; et al. (2000). "Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2". Brain Res. Mol. Brain Res. 74 (1–2): 126–34. PMID 10640683.
- Cousin P, Billotte J, Chaubert P, Shaw P (2000). "Physical map of 17p13 and the genes adjacent to p53". Genomics. 63 (1): 60–8. doi:10.1006/geno.1999.6062. PMID 10662545.
- Franklin A, Kao A, Tapscott S, Unis A (2002). "NeuroD homologue expression during cortical development in the human brain". J. Child Neurol. 16 (11): 849–53. PMID 11732772.
- Westerman BA, Poutsma A, Maruyama K; et al. (2002). "The proneural genes NEUROD1 and NEUROD2 are expressed during human trophoblast invasion". Mech. Dev. 113 (1): 85–90. PMID 11900979.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Westerman BA, Chhatta A, Poutsma A; et al. (2004). "NEUROD1 acts in vitro as an upstream regulator of NEUROD2 in trophoblast cells". Biochim. Biophys. Acta. 1676 (1): 96–103. PMID 14732494.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Zill P, Büttner A, Eisenmenger W, Bondy B (2006). "A possible impact of the neuroD2 transcription factor on the development of drug abusing behavior". Mol. Psychiatry. 11 (6): 525–7. doi:10.1038/sj.mp.4001825. PMID 16607387.
External links
- NEUROD2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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