ARID3A

AT rich interactive domain 3A (BRIGHT-like)
Identifiers
Symbols	ARID3A ; BRIGHT; DRIL1; DRIL3; E2FBP1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3827
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

AT rich interactive domain 3A (BRIGHT-like), also known as ARID3A, is a human gene.

This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification.

Further reading

• Kortschak RD, Tucker PW, Saint R (2000). "ARID proteins come in from the desert". Trends Biochem. Sci. 25 (6): 294–9. PMID 10838570.CS1 maint: Multiple names: authors list (link)
• Kortschak RD, Reimann H, Zimmer M; et al. (1998). "The human dead ringer/bright homolog, DRIL1: cDNA cloning, gene structure, and mapping to D19S886, a marker on 19p13.3 that is strictly linked to the Peutz-Jeghers syndrome". Genomics. 51 (2): 288–92. doi:10.1006/geno.1998.5259. PMID 9722953.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki M, Okuyama S, Okamoto S; et al. (1998). "A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer". Oncogene. 17 (7): 853–65. doi:10.1038/sj.onc.1202163. PMID 9780002.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Peeper DS, Shvarts A, Brummelkamp T; et al. (2002). "A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence". Nat. Cell Biol. 4 (2): 148–53. doi:10.1038/ncb742. PMID 11812999.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kaiwen M (2002). "[Involvement of E2FBP1, an ARID family member protein, in the p53 regulatory pathway]". Kokubyo Gakkai Zasshi. 69 (2): 152–61. PMID 12136662.
• Goebel P, Montalbano A, Ayers N; et al. (2002). "High frequency of matrix attachment regions and cut-like protein x/CCAAT-displacement protein and B cell regulator of IgH transcription binding sites flanking Ig V region genes". J. Immunol. 169 (5): 2477–87. PMID 12193717.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ma K, Araki K, Ichwan SJ; et al. (2004). "E2FBP1/DRIL1, an AT-rich interaction domain-family transcription factor, is regulated by p53". Mol. Cancer Res. 1 (6): 438–44. PMID 12692263.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fukuyo Y, Mogi K, Tsunematsu Y, Nakajima T (2005). "E2FBP1/hDril1 modulates cell growth through downregulation of promyelocytic leukemia bodies". Cell Death Differ. 11 (7): 747–59. doi:10.1038/sj.cdd.4401412. PMID 15017387.CS1 maint: Multiple names: authors list (link)
• Grimwood J, Gordon LA, Olsen A; et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nixon JC, Rajaiya JB, Ayers N; et al. (2004). "The transcription factor, Bright, is not expressed in all human B lymphocyte subpopulations". Cell. Immunol. 228 (1): 42–53. doi:10.1016/j.cellimm.2004.03.004. PMID 15203319.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rajaiya J, Nixon JC, Ayers N; et al. (2006). "Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I". Mol. Cell. Biol. 26 (12): 4758–68. doi:10.1128/MCB.02009-05. PMID 16738337.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin D, Ippolito GC, Zong RT; et al. (2007). "Bright/ARID3A contributes to chromatin accessibility of the immunoglobulin heavy chain enhancer". Mol. Cancer. 6: 23. doi:10.1186/1476-4598-6-23. PMID 17386101.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• ARID3A+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.