GATA5

GATA binding protein 5
Identifiers
Symbols	GATA5 ; bB379O24.1
External IDs	Template:MGI HomoloGene: 32031
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

GATA binding protein 5, also known as GATA5, is a human gene.

The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity.

See also

• GATA transcription factor

Further reading

• Gao X, Sedgwick T, Shi YB, Evans T (1998). "Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation". Mol. Cell. Biol. 18 (5): 2901–11. PMID 9566909.CS1 maint: Multiple names: authors list (link)
• Kakita T, Hasegawa K, Morimoto T; et al. (1999). "p300 protein as a coactivator of GATA-5 in the transcription of cardiac-restricted atrial natriuretic factor gene". J. Biol. Chem. 274 (48): 34096–102. PMID 10567378.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Krasinski SD, Van Wering HM, Tannemaat MR, Grand RJ (2001). "Differential activation of intestinal gene promoters: functional interactions between GATA-5 and HNF-1 alpha". Am. J. Physiol. Gastrointest. Liver Physiol. 281 (1): G69–84. PMID 11408257.CS1 maint: Multiple names: authors list (link)
• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• van Wering HM, Huibregtse IL, van der Zwan SM; et al. (2002). "Physical interaction between GATA-5 and hepatocyte nuclear factor-1alpha results in synergistic activation of the human lactase-phlorizin hydrolase promoter". J. Biol. Chem. 277 (31): 27659–67. doi:10.1074/jbc.M203645200. PMID 12011060.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Benchabane H, Wrana JL (2003). "GATA- and Smad1-dependent enhancers in the Smad7 gene differentially interpret bone morphogenetic protein concentrations". Mol. Cell. Biol. 23 (18): 6646–61. PMID 12944489.
• Akiyama Y, Watkins N, Suzuki H; et al. (2003). "GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer". Mol. Cell. Biol. 23 (23): 8429–39. PMID 14612389.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Divine JK, Staloch LJ, Haveri H; et al. (2004). "GATA-4, GATA-5, and GATA-6 activate the rat liver fatty acid binding protein gene in concert with HNF-1alpha". Am. J. Physiol. Gastrointest. Liver Physiol. 287 (5): G1086–99. doi:10.1152/ajpgi.00421.2003. PMID 14715527.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guo M, Akiyama Y, House MG; et al. (2005). "Hypermethylation of the GATA genes in lung cancer". Clin. Cancer Res. 10 (23): 7917–24. doi:10.1158/1078-0432.CCR-04-1140. PMID 15585625.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wakana K, Akiyama Y, Aso T, Yuasa Y (2006). "Involvement of GATA-4/-5 transcription factors in ovarian carcinogenesis". Cancer Lett. 241 (2): 281–8. doi:10.1016/j.canlet.2005.10.039. PMID 16337738.CS1 maint: Multiple names: authors list (link)
• Guo M, House MG, Akiyama Y; et al. (2006). "Hypermethylation of the GATA gene family in esophageal cancer". Int. J. Cancer. 119 (9): 2078–83. doi:10.1002/ijc.22092. PMID 16823849.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• GATA5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.