PKNOX1

PBX/knotted 1 homeobox 1
File:PBB Protein PKNOX1 image.jpg PDB rendering based on 1x2n.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1x2n​
Identifiers
Symbols	PKNOX1 ; PREP1; pkonx1c
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3363
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE PKNOX1 204195 s at tn.png
File:PBB GE PKNOX1 216004 s at tn.png
File:PBB GE PKNOX1 221883 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

PBX/knotted 1 homeobox 1, also known as PKNOX1, is a human gene.

Further reading

• Allen TD, Zhu YX, Hawley TS, Hawley RG (2001). "TALE homeoproteins as HOX11-interacting partners in T-cell leukemia". Leuk. Lymphoma. 39 (3–4): 241–56. PMID 11342305.CS1 maint: Multiple names: authors list (link)
• Chang CP, Shen WF, Rozenfeld S; et al. (1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. 9 (6): 663–74. PMID 7729685.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Hillier LD, Lennon G, Becker M; et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. PMID 8889549.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Phelan ML, Featherstone MS (1997). "Distinct HOX N-terminal arm residues are responsible for specificity of DNA recognition by HOX monomers and HOX.PBX heterodimers". J. Biol. Chem. 272 (13): 8635–43. PMID 9079695.
• Chen H, Rossier C, Nakamura Y; et al. (1997). "Cloning of a novel homeobox-containing gene, PKNOX1, and mapping to human chromosome 21q22.3". Genomics. 41 (2): 193–200. doi:10.1006/geno.1997.4632. PMID 9143494.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• LeBrun DP, Matthews BP, Feldman BJ, Cleary ML (1997). "The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains". Oncogene. 15 (17): 2059–67. doi:10.1038/sj.onc.1201367. PMID 9366523.CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Berthelsen J, Viggiano L, Schulz H; et al. (1998). "PKNOX1, a gene encoding PREP1, a new regulator of Pbx activity, maps on human chromosome 21q22.3 and murine chromosome 17B/C". Genomics. 47 (2): 323–4. doi:10.1006/geno.1997.5086. PMID 9479508.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Berthelsen J, Zappavigna V, Mavilio F, Blasi F (1998). "Prep1, a novel functional partner of Pbx proteins". EMBO J. 17 (5): 1423–33. doi:10.1093/emboj/17.5.1423. PMID 9482739.CS1 maint: Multiple names: authors list (link)
• Berthelsen J, Zappavigna V, Ferretti E; et al. (1998). "The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity". EMBO J. 17 (5): 1434–45. doi:10.1093/emboj/17.5.1434. PMID 9482740.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Green NC, Rambaldi I, Teakles J, Featherstone MS (1998). "A conserved C-terminal domain in PBX increases DNA binding by the PBX homeodomain and is not a primary site of contact for the YPWM motif of HOXA1". J. Biol. Chem. 273 (21): 13273–9. PMID 9582372.CS1 maint: Multiple names: authors list (link)
• Berthelsen J, Kilstrup-Nielsen C, Blasi F; et al. (1999). "The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH". Genes Dev. 13 (8): 946–53. PMID 10215622.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jacobs Y, Schnabel CA, Cleary ML (1999). "Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity". Mol. Cell. Biol. 19 (7): 5134–42. PMID 10373562.CS1 maint: Multiple names: authors list (link)
• Knoepfler PS, Bergstrom DA, Uetsuki T; et al. (1999). "A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1". Nucleic Acids Res. 27 (18): 3752–61. PMID 10471746.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hattori M, Fujiyama A, Taylor TD; et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kömüves LG, Shen WF, Kwong A; et al. (2000). "Changes in HOXB6 homeodomain protein structure and localization during human epidermal development and differentiation". Dev. Dyn. 218 (4): 636–47. doi:10.1002/1097-0177(2000)9999:9999<::AID-DVDY1014>3.0.CO;2-I. PMID 10906782.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Okada Y, Matsuura E, Nagai R; et al. (2003). "PREP1, MEIS1 homolog protein, regulates PF4 gene expression". Biochem. Biophys. Res. Commun. 305 (1): 155–9. PMID 12732210.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• PKNOX1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.