PRDM1
| PR domain containing 1, with ZNF domain | |||||||||||
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| Identifiers | |||||||||||
| Symbols | PRDM1 ; BLIMP1; MGC118922; MGC118923; MGC118924; MGC118925; PRDI-BF1 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 925 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE PRDM1 217192 s at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
PR domain containing 1, with ZNF domain, also known as PRDM1, is a human gene.[1]
This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported.[1]
References
Further reading
- Keller AD, Maniatis T (1991). "Identification and characterization of a novel repressor of beta-interferon gene expression". Genes Dev. 5 (5): 868–79. PMID 1851123.
- Huang S (1994). "Blimp-1 is the murine homolog of the human transcriptional repressor PRDI-BF1". Cell. 78 (1): 9. PMID 8033216.
- Turner CA, Mack DH, Davis MM (1994). "Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells". Cell. 77 (2): 297–306. PMID 8168136.
- Mock BA, Liu L, LePaslier D, Huang S (1997). "The B-lymphocyte maturation promoting transcription factor BLIMP1/PRDI-BF1 maps to D6S447 on human chromosome 6q21-q22.1 and the syntenic region of mouse chromosome 10". Genomics. 37 (1): 24–8. PMID 8921366.
- Ren B, Chee KJ, Kim TH, Maniatis T (1999). "PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins". Genes Dev. 13 (1): 125–37. PMID 9887105.
- Angelin-Duclos C, Cattoretti G, Lin KI, Calame K (2000). "Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo". J. Immunol. 165 (10): 5462–71. PMID 11067898.
- Gupta S, Anthony A, Pernis AB (2001). "Stage-specific modulation of IFN-regulatory factor 4 function by Krüppel-type zinc finger proteins". J. Immunol. 166 (10): 6104–11. PMID 11342629.
- Medina F, Segundo C, Campos-Caro A; et al. (2002). "The heterogeneity shown by human plasma cells from tonsil, blood, and bone marrow reveals graded stages of increasing maturity, but local profiles of adhesion molecule expression". Blood. 99 (6): 2154–61. PMID 11877292.
- Shaffer AL, Lin KI, Kuo TC; et al. (2002). "Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program". Immunity. 17 (1): 51–62. PMID 12150891.
- Vasanwala FH, Kusam S, Toney LM, Dent AL (2002). "Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene". J. Immunol. 169 (4): 1922–9. PMID 12165517.
- Borson ND, Lacy MQ, Wettstein PJ (2003). "Altered mRNA expression of Pax5 and Blimp-1 in B cells in multiple myeloma". Blood. 100 (13): 4629–39. doi:10.1182/blood.V100.13.4629. PMID 12453881.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Györy I, Fejér G, Ghosh N; et al. (2003). "Identification of a functionally impaired positive regulatory domain I binding factor 1 transcription repressor in myeloma cell lines". J. Immunol. 170 (6): 3125–33. PMID 12626569.
- Gyory I, Wu J, Fejér G; et al. (2004). "PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing". Nat. Immunol. 5 (3): 299–308. doi:10.1038/ni1046. PMID 14985713.
- Lotz C, Mutallib SA, Oehlrich N; et al. (2005). "Targeting positive regulatory domain I-binding factor 1 and X box-binding protein 1 transcription factors by multiple myeloma-reactive CTL". J. Immunol. 175 (2): 1301–9. PMID 16002735.
- Tam W, Gomez M, Chadburn A; et al. (2006). "Mutational analysis of PRDM1 indicates a tumor-suppressor role in diffuse large B-cell lymphomas". Blood. 107 (10): 4090–100. doi:10.1182/blood-2005-09-3778. PMID 16424392.
- Pasqualucci L, Compagno M, Houldsworth J; et al. (2006). "Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma". J. Exp. Med. 203 (2): 311–7. doi:10.1084/jem.20052204. PMID 16492805.
- González-García I, Ocaña E, Jiménez-Gómez G; et al. (2006). "Immunization-induced perturbation of human blood plasma cell pool: progressive maturation, IL-6 responsiveness, and high PRDI-BF1/BLIMP1 expression are critical distinctions between antigen-specific and nonspecific plasma cells". J. Immunol. 176 (7): 4042–50. PMID 16547239.
- Garcia JF, Roncador G, García JF; et al. (2006). "PRDM1/BLIMP-1 expression in multiple B and T-cell lymphoma". Haematologica. 91 (4): 467–74. PMID 16585013.
- Lim J, Hao T, Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
External links
- PRDM1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.