TFAP2A
| Transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) | |||||||||||
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| Identifiers | |||||||||||
| Symbols | TFAP2A ; AP-2; AP-2alpha; AP2TF; TFAP2 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 2421 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE TFAP2A 204653 at tn.png | |||||||||||
| File:PBB GE TFAP2A 204654 s at tn.png | |||||||||||
| File:PBB GE TFAP2A 210669 at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha), also known as TFAP2A, is a human gene.[1]
AP2-alpha is a 52-kD retinoic acid-inducible and developmentally regulated activator of transcription that binds to a consensus DNA-binding sequence CCCCAGGC in the SV40 and metallothionein (MIM 156350) promoters.[supplied by OMIM][1]
See also
References
Further reading
- Murphy JE, Keen JH (1992). "Recognition sites for clathrin-associated proteins AP-2 and AP-3 on clathrin triskelia". J. Biol. Chem. 267 (15): 10850–5. PMID 1587861.
- Gaynor RB, Muchardt C, Xia YR; et al. (1991). "Localization of the gene for the DNA-binding protein AP-2 to human chromosome 6p22.3-pter". Genomics. 10 (4): 1100–2. PMID 1916817.
- Williams T, Tjian R (1991). "Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins". Science. 251 (4997): 1067–71. PMID 1998122.
- Williams T, Tjian R (1991). "Analysis of the DNA-binding and activation properties of the human transcription factor AP-2". Genes Dev. 5 (4): 670–82. PMID 2010091.
- Williams T, Admon A, Lüscher B, Tjian R (1989). "Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements". Genes Dev. 2 (12A): 1557–69. PMID 3063603.
- Bauer R, Imhof A, Pscherer A; et al. (1994). "The genomic structure of the human AP-2 transcription factor". Nucleic Acids Res. 22 (8): 1413–20. PMID 8190633.
- Buettner R, Kannan P, Imhof A; et al. (1993). "An alternatively spliced mRNA from the AP-2 gene encodes a negative regulator of transcriptional activation by AP-2". Mol. Cell. Biol. 13 (7): 4174–85. PMID 8321221.
- Williamson JA, Bosher JM, Skinner A; et al. (1996). "Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription factors". Genomics. 35 (1): 262–4. doi:10.1006/geno.1996.0351. PMID 8661133.
- Pirozzi G, McConnell SJ, Uveges AJ; et al. (1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets". J. Biol. Chem. 272 (23): 14611–6. PMID 9169421.
- Batsché E, Muchardt C, Behrens J; et al. (1998). "RB and c-Myc activate expression of the E-cadherin gene in epithelial cells through interaction with transcription factor AP-2". Mol. Cell. Biol. 18 (7): 3647–58. PMID 9632747.
- Mertens PR, Alfonso-Jaume MA, Steinmann K, Lovett DH (1999). "A synergistic interaction of transcription factors AP2 and YB-1 regulates gelatinase A enhancer-dependent transcription". J. Biol. Chem. 273 (49): 32957–65. PMID 9830047.
- García MA, Campillos M, Marina A; et al. (1999). "Transcription factor AP-2 activity is modulated by protein kinase A-mediated phosphorylation". FEBS Lett. 444 (1): 27–31. PMID 10037142.
- Rosenthal JA, Chen H, Slepnev VI; et al. (1999). "The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module". J. Biol. Chem. 274 (48): 33959–65. PMID 10567358.
- Heicklen-Klein A, Ginzburg I (2000). "Tau promoter confers neuronal specificity and binds Sp1 and AP-2". J. Neurochem. 75 (4): 1408–18. PMID 10987820.
- Nyormoi O, Wang Z, Doan D; et al. (2001). "Transcription factor AP-2alpha is preferentially cleaved by caspase 6 and degraded by proteasome during tumor necrosis factor alpha-induced apoptosis in breast cancer cells". Mol. Cell. Biol. 21 (15): 4856–67. doi:10.1128/MCB.21.15.4856-4867.2001. PMID 11438643.
- Rao DS, Chang JC, Kumar PD; et al. (2001). "Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors". Mol. Cell. Biol. 21 (22): 7796–806. doi:10.1128/MCB.21.22.7796-7806.2001. PMID 11604514.
- Bragança J, Swingler T, Marques FI; et al. (2002). "Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2". J. Biol. Chem. 277 (10): 8559–65. doi:10.1074/jbc.M110850200. PMID 11744733.
- Mertens PR, Steinmann K, Alfonso-Jaume MA; et al. (2002). "Combinatorial interactions of p53, activating protein-2, and YB-1 with a single enhancer element regulate gelatinase A expression in neoplastic cells". J. Biol. Chem. 277 (28): 24875–82. doi:10.1074/jbc.M200445200. PMID 11973333.
- Eloranta JJ, Hurst HC (2002). "Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo". J. Biol. Chem. 277 (34): 30798–804. doi:10.1074/jbc.M202780200. PMID 12072434.
- Ben-Zimra M, Koler M, Orly J (2003). "Transcription of cholesterol side-chain cleavage cytochrome P450 in the placenta: activating protein-2 assumes the role of steroidogenic factor-1 by binding to an overlapping promoter element". Mol. Endocrinol. 16 (8): 1864–80. PMID 12145340.
External links
- TFAP2A+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.