PBX2
| Pre-B-cell leukemia homeobox 2 | |||||||||||||
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File:PBB Protein PBX2 image.jpg PDB rendering based on 1b72. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | PBX2 ; G17; HOX12; PBX2MHC | ||||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 48115 | ||||||||||||
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| RNA expression pattern | |||||||||||||
| File:PBB GE PBX2 202876 s at tn.png | |||||||||||||
| File:PBB GE PBX2 202875 s at tn.png | |||||||||||||
| File:PBB GE PBX2 211096 at tn.png | |||||||||||||
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| Template:GNF Ortholog box | |||||||||||||
| Species | Human | Mouse | |||||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||||
| RefSeq (protein) | n/a | n/a | |||||||||||
| Location (UCSC) | n/a | n/a | |||||||||||
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Pre-B-cell leukemia homeobox 2, also known as PBX2, is a human gene.[1]
This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.[1]
References
Further reading
- Monica K, Galili N, Nourse J; et al. (1991). "PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1". Mol. Cell. Biol. 11 (12): 6149–57. PMID 1682799.
- Aguado B, Campbell RD (1995). "The novel gene G17, located in the human major histocompatibility complex, encodes PBX2, a homeodomain-containing protein". Genomics. 25 (3): 650–9. PMID 7759099.
- Sugaya K, Fukagawa T, Matsumoto K; et al. (1995). "Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3". Genomics. 23 (2): 408–19. PMID 7835890.
- Lu Q, Wright DD, Kamps MP (1994). "Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation". Mol. Cell. Biol. 14 (6): 3938–48. PMID 7910944.
- Katsanis N, Fitzgibbon J, Fisher EM (1996). "Paralogy mapping: identification of a region in the human MHC triplicated onto human chromosomes 1 and 9 allows the prediction and isolation of novel PBX and NOTCH loci". Genomics. 35 (1): 101–8. doi:10.1006/geno.1996.0328. PMID 8661110.
- Berthelsen J, Zappavigna V, Mavilio F, Blasi F (1998). "Prep1, a novel functional partner of Pbx proteins". EMBO J. 17 (5): 1423–33. doi:10.1093/emboj/17.5.1423. PMID 9482739.
- Shen WF, Rozenfeld S, Kwong A; et al. (1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Mol. Cell. Biol. 19 (4): 3051–61. PMID 10082572.
- Fujino T, Yamazaki Y, Largaespada DA; et al. (2001). "Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes". Exp. Hematol. 29 (7): 856–63. PMID 11438208.
- Brake RL, Kees UR, Watt PM (2002). "A complex containing PBX2 contributes to activation of the proto-oncogene HOX11". Biochem. Biophys. Res. Commun. 294 (1): 23–34. doi:10.1016/S0006-291X(02)00426-6. PMID 12054735.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Okada Y, Nagai R, Sato T; et al. (2004). "Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene". Blood. 101 (12): 4748–56. doi:10.1182/blood-2002-02-0380. PMID 12609849.
- Longobardi E, Blasi F (2003). "Overexpression of PREP-1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradation". J. Biol. Chem. 278 (40): 39235–41. doi:10.1074/jbc.M304704200. PMID 12871956.
- Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Xie T, Rowen L, Aguado B; et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMID 14656967.
- Lehner B, Semple JI, Brown SE; et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. PMID 14667819.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
External links
- PBX2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.