CBX3

Chromobox homolog 3 (HP1 gamma homolog, Drosophila)
Identifiers
Symbols	CBX3 ; HECH; HP1-GAMMA; HP1Hs-gamma
External IDs	Template:OMIM5 Template:MGI HomoloGene: 40583
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Chromobox homolog 3 (HP1 gamma homolog, Drosophila), also known as CBX3, is a human gene.

At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.

See also

• Heterochromatin protein 1

Further reading

• Ye Q, Worman HJ (1996). "Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1". J. Biol. Chem. 271 (25): 14653–6. PMID 8663349.
• Ye Q, Callebaut I, Pezhman A; et al. (1997). "Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR". J. Biol. Chem. 272 (23): 14983–9. PMID 9169472.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lessard J, Baban S, Sauvageau G (1998). "Stage-specific expression of polycomb group genes in human bone marrow cells". Blood. 91 (4): 1216–24. PMID 9454751.CS1 maint: Multiple names: authors list (link)
• Seeler JS, Marchio A, Sitterlin D; et al. (1998). "Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment". Proc. Natl. Acad. Sci. U.S.A. 95 (13): 7316–21. PMID 9636146.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lehming N, Le Saux A, Schüller J, Ptashne M (1998). "Chromatin components as part of a putative transcriptional repressing complex". Proc. Natl. Acad. Sci. U.S.A. 95 (13): 7322–6. PMID 9636147.CS1 maint: Multiple names: authors list (link)
• Ainsztein AM, Kandels-Lewis SE, Mackay AM, Earnshaw WC (1999). "INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1". J. Cell Biol. 143 (7): 1763–74. PMID 9864353.CS1 maint: Multiple names: authors list (link)
• Ryan RF, Schultz DC, Ayyanathan K; et al. (1999). "KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Krüppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing". Mol. Cell. Biol. 19 (6): 4366–78. PMID 10330177.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Minc E, Allory Y, Worman HJ; et al. (1999). "Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells". Chromosoma. 108 (4): 220–34. PMID 10460410.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nielsen AL, Ortiz JA, You J; et al. (2000). "Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family". EMBO J. 18 (22): 6385–95. doi:10.1093/emboj/18.22.6385. PMID 10562550.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Koike N, Maita H, Taira T; et al. (2000). "Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1)". FEBS Lett. 467 (1): 17–21. PMID 10664448.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Minc E, Courvalin JC, Buendia B (2001). "HP1gamma associates with euchromatin and heterochromatin in mammalian nuclei and chromosomes". Cytogenet. Cell Genet. 90 (3–4): 279–84. PMID 11124534.CS1 maint: Multiple names: authors list (link)
• Lachner M, O'Carroll D, Rea S; et al. (2001). "Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins". Nature. 410 (6824): 116–20. doi:10.1038/35065132. PMID 11242053.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nielsen AL, Oulad-Abdelghani M, Ortiz JA; et al. (2001). "Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins". Mol. Cell. 7 (4): 729–39. PMID 11336697.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scholzen T, Endl E, Wohlenberg C; et al. (2002). "The Ki-67 protein interacts with members of the heterochromatin protein 1 (HP1) family: a potential role in the regulation of higher-order chromatin structure". J. Pathol. 196 (2): 135–44. doi:10.1002/path.1016. PMID 11793364.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vassallo MF, Tanese N (2002). "Isoform-specific interaction of HP1 with human TAFII130". Proc. Natl. Acad. Sci. U.S.A. 99 (9): 5919–24. doi:10.1073/pnas.092025499. PMID 11959914.
• Ogawa H, Ishiguro K, Gaubatz S; et al. (2002). "A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells". Science. 296 (5570): 1132–6. doi:10.1126/science.1069861. PMID 12004135.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hwang KK, Worman HJ (2002). "Gene regulation by human orthologs of Drosophila heterochromatin protein 1". Biochem. Biophys. Res. Commun. 293 (4): 1217–22. doi:10.1016/S0006-291X(02)00377-7. PMID 12054505.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kametaka A, Takagi M, Hayakawa T; et al. (2003). "Interaction of the chromatin compaction-inducing domain (LR domain) of Ki-67 antigen with HP1 proteins". Genes Cells. 7 (12): 1231–42. PMID 12485163.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cheutin T, McNairn AJ, Jenuwein T; et al. (2003). "Maintenance of stable heterochromatin domains by dynamic HP1 binding". Science. 299 (5607): 721–5. doi:10.1126/science.1078572. PMID 12560555.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• CBX3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.