HOXA11

Homeobox A11
Identifiers
Symbols	HOXA11 ; HOX1; HOX1I
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4033
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Homeobox A11, also known as HOXA11, is a human gene.

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia.

See also

• Homeobox

Further reading

• Daftary GS, Taylor HS (2001). "Implantation in the human: the role of HOX genes". Semin. Reprod. Med. 18 (3): 311–20. PMID 11299969.
• Daftary GS, Taylor HS (2001). "Molecular markers of implantation: clinical implications". Curr. Opin. Obstet. Gynecol. 13 (3): 269–74. PMID 11396649.
• Davies JA, Fisher CE (2002). "Genes and proteins in renal development". Exp. Nephrol. 10 (2): 102–13. PMID 11937757.
• Eun Kwon H, Taylor HS (2005). "The role of HOX genes in human implantation". Ann. N. Y. Acad. Sci. 1034: 1–18. doi:10.1196/annals.1335.001. PMID 15731295.
• Scott MP (1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. PMID 1358459.
• McAlpine PJ, Shows TB (1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. PMID 1973146.
• Acampora D, D'Esposito M, Faiella A; et al. (1990). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402. PMID 2574852.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miano JM, Firulli AB, Olson EN; et al. (1996). "Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells". Proc. Natl. Acad. Sci. U.S.A. 93 (2): 900–5. PMID 8570656.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Apiou F, Flagiello D, Cillo C; et al. (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–5. PMID 8646877.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Potter SS, Branford WW (1998). "Evolutionary conservation and tissue-specific processing of Hoxa 11 antisense transcripts". Mamm. Genome. 9 (10): 799–806. PMID 9745033.
• Taylor HS, Igarashi P, Olive DL, Arici A (1999). "Sex steroids mediate HOXA11 expression in the human peri-implantation endometrium". J. Clin. Endocrinol. Metab. 84 (3): 1129–35. PMID 10084606.CS1 maint: Multiple names: authors list (link)
• Thompson AA, Nguyen LT (2001). "Amegakaryocytic thrombocytopenia and radio-ulnar synostosis are associated with HOXA11 mutation". Nat. Genet. 26 (4): 397–8. doi:10.1038/82511. PMID 11101832.
• Shen WF, Krishnan K, Lawrence HJ, Largman C (2001). "The HOX homeodomain proteins block CBP histone acetyltransferase activity". Mol. Cell. Biol. 21 (21): 7509–22. doi:10.1128/MCB.21.21.7509-7522.2001. PMID 11585930.CS1 maint: Multiple names: authors list (link)
• Fujino T, Suzuki A, Ito Y; et al. (2002). "Single-translocation and double-chimeric transcripts: detection of NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15)". Blood. 99 (4): 1428–33. PMID 11830496.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fleischman RA, Letestu R, Mi X; et al. (2002). "Absence of mutations in the HoxA10, HoxA11 and HoxD11 nucleotide coding sequences in thrombocytopenia with absent radius syndrome". Br. J. Haematol. 116 (2): 367–75. PMID 11841440.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kosaki K, Kosaki R, Suzuki T; et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chau YM, Pando S, Taylor HS (2002). "HOXA11 silencing and endogenous HOXA11 antisense ribonucleic acid in the uterine endometrium". J. Clin. Endocrinol. Metab. 87 (6): 2674–80. PMID 12050232.CS1 maint: Multiple names: authors list (link)

External links

• HOXA11+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.