RAR-related orphan receptor beta

RAR-related orphan receptor B
File:PBB Protein RORB image.jpg PDB rendering based on 1k4w.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1k4w​, 1n4h​, 1nq7​
Identifiers
Symbols	RORB ; NR1F2; ROR-BETA; RZRB; bA133M9.1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 38250
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RORB 206443 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

RAR-related orphan receptor beta (ROR-beta), also known as NR1F2 (nuclear receptor subfamily 1, group F, member 2) is a nuclear receptor encoded by the RORB gene.

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation.

Further reading

• Beeson WM, Perry TW, Zurcher TD (1977). "Effect of supplemental zinc on growth and on hair and blood serum levels of beef cattle". J. Anim. Sci. 45 (1): 160–5. PMID 885817.CS1 maint: Multiple names: authors list (link)
• Giguère V, Tini M, Flock G; et al. (1994). "Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors". Genes Dev. 8 (5): 538–53. PMID 7926749.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Carlberg C, Hooft van Huijsduijnen R, Staple JK; et al. (1994). "RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers". Mol. Endocrinol. 8 (6): 757–70. PMID 7935491.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Greiner EF, Kirfel J, Greschik H; et al. (1996). "Functional analysis of retinoid Z receptor beta, a brain-specific nuclear orphan receptor". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10105–10. PMID 8816759.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Paravicini G, Steinmayr M, André E, Becker-André M (1996). "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily". Biochem. Biophys. Res. Commun. 227 (1): 82–7. doi:10.1006/bbrc.1996.1471. PMID 8858107.CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Park HT, Baek SY, Kim BS; et al. (1997). "Developmental expression of 'RZR beta, a putative nuclear-melatonin receptor' mRNA in the suprachiasmatic nucleus of the rat". Neurosci. Lett. 217 (1): 17–20. PMID 8905729.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• André E, Conquet F, Steinmayr M; et al. (1998). "Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice". EMBO J. 17 (14): 3867–77. doi:10.1093/emboj/17.14.3867. PMID 9670004.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Greiner EF, Kirfel J, Greschik H; et al. (2000). "Differential ligand-dependent protein-protein interactions between nuclear receptors and a neuronal-specific cofactor". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7160–5. PMID 10860982.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gawlas K, Stunnenberg HG (2001). "Differential binding and transcriptional behaviour of two highly related orphan receptors, ROR alpha(4) and ROR beta(1)". Biochim. Biophys. Acta. 1494 (3): 236–41. PMID 11121580.
• Gawlas K, Stunnenberg HG (2001). "Differential transcription of the orphan receptor RORbeta in nuclear extracts derived from Neuro2A and HeLa cells". Nucleic Acids Res. 29 (16): 3424–32. PMID 11504880.
• Stehlin C, Wurtz JM, Steinmetz A; et al. (2001). "X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation". EMBO J. 20 (21): 5822–31. doi:10.1093/emboj/20.21.5822. PMID 11689423.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sumi Y, Yagita K, Yamaguchi S; et al. (2002). "Rhythmic expression of ROR beta mRNA in the mice suprachiasmatic nucleus". Neurosci. Lett. 320 (1–2): 13–6. PMID 11849752.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stehlin-Gaon C, Willmann D, Zeyer D; et al. (2003). "All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta". Nat. Struct. Biol. 10 (10): 820–5. doi:10.1038/nsb979. PMID 12958591.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Humphray SJ, Oliver K, Hunt AR; et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)