Myeloid cell Nuclear Differentiation Antigen is a protein that in humans is encoded as MNDAgene.[1][2][3]
The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5' UTR, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.[3]
References
↑Briggs JA, Burrus GR, Stickney BD, Briggs RC (Sep 1992). "Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha". J Cell Biochem. 49 (1): 82–92. doi:10.1002/jcb.240490114. PMID1644857.
↑Briggs RC, Briggs JA, Ozer J, Sealy L, Dworkin LL, Kingsmore SF, Seldin MF, Kaur GP, Athwal RS, Dessypris EN (May 1994). "The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located on chromosome 1q that are expressed specifically in hematopoietic cells". Blood. 83 (8): 2153–62. PMID7512843.
Burrus GR, Briggs JA, Briggs RC (1992). "Characterization of the human myeloid cell nuclear differentiation antigen: relationship to interferon-inducible proteins". J. Cell. Biochem. 48 (2): 190–202. doi:10.1002/jcb.240480210. PMID1377701.
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Dawson MJ, Trapani JA, Briggs RC, et al. (1995). "The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression". Immunogenetics. 41 (1): 40–3. doi:10.1007/BF00188431. PMID7806273.
Briggs R, Dworkin L, Briggs J, et al. (1994). "Interferon alpha selectively affects expression of the human myeloid cell nuclear differentiation antigen in late stage cells in the monocytic but not the granulocytic lineage". J. Cell. Biochem. 54 (2): 198–206. doi:10.1002/jcb.240540208. PMID8175894.
Doggett KL, Briggs JA, Linton MF, et al. (2002). "Retroviral mediated expression of the human myeloid nuclear antigen in a null cell line upregulates Dlk1 expression". J. Cell. Biochem. 86 (1): 56–66. doi:10.1002/jcb.10190. PMID12112016.
Fukushi M, Higuchi M, Oie M, et al. (2004). "Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts with human myeloid cell nuclear differentiation antigen induced by interferon alpha". Virus Genes. 27 (3): 237–47. doi:10.1023/A:1026391715071. PMID14618084.
Briggs RC, Atkinson JB, Miranda RN (2005). "Variable expression of human myeloid specific nuclear antigen MNDA in monocyte lineage cells in atherosclerosis". J. Cell. Biochem. 95 (2): 293–301. doi:10.1002/jcb.20435. PMID15778972.
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Briggs RC, Shults KE, Flye LA, et al. (2006). "Dysregulated human myeloid nuclear differentiation antigen expression in myelodysplastic syndromes: evidence for a role in apoptosis". Cancer Res. 66 (9): 4645–51. doi:10.1158/0008-5472.CAN-06-0229. PMID16651415.
