C-Fos

V-fos FBJ murine osteosarcoma viral oncogene homolog
PDB rendering based on 1a02.
Identifiers
Symbols	FOS ; c-fos
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3844
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

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List of terms related to C-Fos

Overview

In molecular biology, c-Fos is a cellular proto-oncogene belonging to the immediate early gene family of transcription factors. c-Fos has a leucine-zipper DNA binding domain, and a transactivation domain at the C-terminus. Transcription of c-Fos is upregulated in response to many extracellular signals, e.g. growth factors. Additionally, phosphorylation by MAPK, PKA, PKC or cdc2 alters the activity and stability of c-Fos. Members of the Fos family dimerise with Jun to form the AP-1 transcription factor, which upregulates transcription of a diverse range of genes involved in everything from proliferation and differentiation to defense against invasion and cell damage.

The AP-1 complex has been implemented in transformation and progression of cancer, and both Fos and Jun were first discovered in rat fibroblasts.

The viral homologue of c-Fos, v-Fos, is found in the retrovirus Finkel–Biskis–Jinkins murine osteogenic sarcoma virus.

See also

• Leptomycin
• Jun
• Egr-1

Further reading

• Murphy LC, Alkhalaf M, Dotzlaw H; et al. (1994). "Regulation of gene expression in T-47D human breast cancer cells by progestins and antiprogestins". Hum. Reprod. 9 Suppl 1: 174–80. PMID 7962462.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pompeiano M, Cirelli C, Arrighi P, Tononi G (1997). "c-Fos expression during wakefulness and sleep". Neurophysiologie clinique = Clinical neurophysiology. 25 (6): 329–41. doi:10.1016/0987-7053(96)84906-9. PMID 8904195.CS1 maint: Multiple names: authors list (link)
• Herrera DG, Robertson HA (1997). "Activation of c-fos in the brain". Prog. Neurobiol. 50 (2–3): 83–107. PMID 8971979.
• Velazquez Torres A, Gariglio Vidal P (2002). "[Possible role of transcription factor AP1 in the tissue-specific regulation of human papillomavirus]". Rev. Invest. Clin. 54 (3): 231–42. PMID 12183893.

References

1. Karin Milde-Langosch, 2005. The Fos family of transcription factors and their role in tumourigenesis. European Journal of Cancer 41(16):2449-2461. Abstract + Full Text

External links

• c-fos+Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)
• c-fos+Genes at the US National Library of Medicine Medical Subject Headings (MeSH)