BHLHB2
| Basic helix-loop-helix domain containing, class B, 2 | |||||||||||
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| Symbols | BHLHB2 ; DEC1; SHARP-2; STRA13; Stra14 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 2722 | ||||||||||
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| Species | Human | Mouse | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
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Basic helix-loop-helix domain containing, class B, 2, also known as BHLHB2, is a human gene.[1]
DEC1 encodes a basic helix-loop-helix protein expressed in various tissues. Expression in the chondrocytes is responsive to the addition of Bt2cAMP. Differentiated embryo chondrocyte expressed gene 1 is believed to be involved in the control of cell differentiation.[1]
References
Further reading
- Shen M, Kawamoto T, Yan W; et al. (1997). "Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes". Biochem. Biophys. Res. Commun. 236 (2): 294–8. doi:10.1006/bbrc.1997.6960. PMID 9240428.
- Antonevich T, Taneja R (1999). "Assignment1 of the human Stra13 gene (STRA13) to chromosome 3p26 by in situ hybridization". Cytogenet. Cell Genet. 85 (3–4): 254–5. PMID 10449910.
- Teramoto M, Nakamasu K, Noshiro M; et al. (2001). "Gene structure and chromosomal location of a human bHLH transcriptional factor DEC1 x Stra13 x SHARP-2/BHLHB2". J. Biochem. 129 (3): 391–6. PMID 11226878.
- Ivanova AV, Ivanov SV, Danilkovitch-Miagkova A, Lerman MI (2001). "Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway". J. Biol. Chem. 276 (18): 15306–15. doi:10.1074/jbc.M010516200. PMID 11278694.
- Sun H, Lu B, Li RQ; et al. (2001). "Defective T cell activation and autoimmune disorder in Stra13-deficient mice". Nat. Immunol. 2 (11): 1040–7. doi:10.1038/ni721. PMID 11668339.
- Yoon DY, Buchler P, Saarikoski ST; et al. (2001). "Identification of genes differentially induced by hypoxia in pancreatic cancer cells". Biochem. Biophys. Res. Commun. 288 (4): 882–6. doi:10.1006/bbrc.2001.5867. PMID 11688991.
- Li Y, Zhang H, Xie M; et al. (2002). "Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation". Biochem. J. 367 (Pt 2): 413–22. doi:10.1042/BJ20020514. PMID 12119049.
- St-Pierre B, Flock G, Zacksenhaus E, Egan SE (2003). "Stra13 homodimers repress transcription through class B E-box elements". J. Biol. Chem. 277 (48): 46544–51. doi:10.1074/jbc.M111652200. PMID 12297495.
- Miyazaki K, Kawamoto T, Tanimoto K; et al. (2003). "Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes". J. Biol. Chem. 277 (49): 47014–21. doi:10.1074/jbc.M204938200. PMID 12354771.
- Shen M, Yoshida E, Yan W; et al. (2003). "Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages". J. Biol. Chem. 277 (51): 50112–20. doi:10.1074/jbc.M206771200. PMID 12384505.
- Honma S, Kawamoto T, Takagi Y; et al. (2002). "Dec1 and Dec2 are regulators of the mammalian molecular clock". Nature. 419 (6909): 841–4. doi:10.1038/nature01123. PMID 12397359.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Li Y, Xie M, Song X; et al. (2003). "DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter". J. Biol. Chem. 278 (19): 16899–907. doi:10.1074/jbc.M300596200. PMID 12624110.
- Giatromanolaki A, Koukourakis MI, Sivridis E; et al. (2003). "DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer". J. Pathol. 200 (2): 222–8. doi:10.1002/path.1330. PMID 12754744.
- Ivanova AV, Ivanov SV, Zhang X; et al. (2004). "STRA13 interacts with STAT3 and modulates transcription of STAT3-dependent targets". J. Mol. Biol. 340 (4): 641–53. doi:10.1016/j.jmb.2004.05.025. PMID 15223310.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Sato F, Kawamoto T, Fujimoto K; et al. (2005). "Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1". Eur. J. Biochem. 271 (22): 4409–19. doi:10.1111/j.1432-1033.2004.04379.x. PMID 15560782.
- Ivanova AV, Ivanov SV, Lerman ML (2005). "Association, mutual stabilization, and transcriptional activity of the STRA13 and MSP58 proteins". Cell. Mol. Life Sci. 62 (4): 471–84. doi:10.1007/s00018-004-4423-2. PMID 15719173.
- Ivanova A, Liao SY, Lerman MI; et al. (2006). "STRA13 expression and subcellular localisation in normal and tumour tissues: implications for use as a diagnostic and differentiation marker". J. Med. Genet. 42 (7): 565–76. doi:10.1136/jmg.2004.029835. PMID 15994878.
- Stelzl U, Worm U, Lalowski M; et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
External links
- BHLHB2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.