CBX1

Chromobox homolog 1 (HP1 beta homolog Drosophila )
PDB rendering based on 1ap0.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1ap0​, 1dz1​, 1guw​, 1s4z​, 2fmm​
Identifiers
Symbols	CBX1 ; CBX; HP1-BETA; HP1Hs-beta; M31; MOD1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 38228
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Chromobox homolog 1 (HP1 beta homolog Drosophila ), also known as CBX1, is a human gene.

Heterochromatin protein-1 (HP1) is localized at heterochromatin sites, where it mediates gene silencing.[supplied by OMIM]

See also

• Heterochromatin protein 1

Further reading

• Furuta K, Chan EK, Kiyosawa K; et al. (1997). "Heterochromatin protein HP1Hsbeta (p25beta) and its localization with centromeres in mitosis". Chromosoma. 106 (1): 11–9. PMID 9169582.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lessard J, Baban S, Sauvageau G (1998). "Stage-specific expression of polycomb group genes in human bone marrow cells". Blood. 91 (4): 1216–24. PMID 9454751.CS1 maint: Multiple names: authors list (link)
• Aagaard L, Laible G, Selenko P; et al. (1999). "Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31". EMBO J. 18 (7): 1923–38. doi:10.1093/emboj/18.7.1923. PMID 10202156.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Minc E, Allory Y, Worman HJ; et al. (1999). "Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells". Chromosoma. 108 (4): 220–34. PMID 10460410.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Murzina N, Verreault A, Laue E, Stillman B (1999). "Heterochromatin dynamics in mouse cells: interaction between chromatin assembly factor 1 and HP1 proteins". Mol. Cell. 4 (4): 529–40. PMID 10549285.CS1 maint: Multiple names: authors list (link)
• Nielsen AL, Ortiz JA, You J; et al. (2000). "Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family". EMBO J. 18 (22): 6385–95. doi:10.1093/emboj/18.22.6385. PMID 10562550.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brasher SV, Smith BO, Fogh RH; et al. (2000). "The structure of mouse HP1 suggests a unique mode of single peptide recognition by the shadow chromo domain dimer". EMBO J. 19 (7): 1587–97. doi:10.1093/emboj/19.7.1587. PMID 10747027.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhao T, Heyduk T, Allis CD, Eissenberg JC (2000). "Heterochromatin protein 1 binds to nucleosomes and DNA in vitro". J. Biol. Chem. 275 (36): 28332–8. doi:10.1074/jbc.M003493200. PMID 10882726.CS1 maint: Multiple names: authors list (link)
• Lachner M, O'Carroll D, Rea S; et al. (2001). "Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins". Nature. 410 (6824): 116–20. doi:10.1038/35065132. PMID 11242053.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bannister AJ, Zegerman P, Partridge JF; et al. (2001). "Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain". Nature. 410 (6824): 120–4. doi:10.1038/35065138. PMID 11242054.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nielsen AL, Oulad-Abdelghani M, Ortiz JA; et al. (2001). "Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins". Mol. Cell. 7 (4): 729–39. PMID 11336697.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Andersen JS, Lyon CE, Fox AH; et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. PMID 11790298.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scholzen T, Endl E, Wohlenberg C; et al. (2002). "The Ki-67 protein interacts with members of the heterochromatin protein 1 (HP1) family: a potential role in the regulation of higher-order chromatin structure". J. Pathol. 196 (2): 135–44. doi:10.1002/path.1016. PMID 11793364.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nielsen PR, Nietlispach D, Mott HR; et al. (2002). "Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9". Nature. 416 (6876): 103–7. doi:10.1038/nature722. PMID 11882902.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vassallo MF, Tanese N (2002). "Isoform-specific interaction of HP1 with human TAFII130". Proc. Natl. Acad. Sci. U.S.A. 99 (9): 5919–24. doi:10.1073/pnas.092025499. PMID 11959914.
• Hwang KK, Worman HJ (2002). "Gene regulation by human orthologs of Drosophila heterochromatin protein 1". Biochem. Biophys. Res. Commun. 293 (4): 1217–22. doi:10.1016/S0006-291X(02)00377-7. PMID 12054505.
• Bhattacharya N, Wang Z, Davitt C; et al. (2003). "Pim-1 associates with protein complexes necessary for mitosis". Chromosoma. 111 (2): 80–95. doi:10.1007/s00412-002-0192-6. PMID 12111331.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin CY, Li CC, Huang PH, Lee FJ (2003). "A developmentally regulated ARF-like 5 protein (ARL5), localized to nuclei and nucleoli, interacts with heterochromatin protein 1". J. Cell. Sci. 115 (Pt 23): 4433–45. PMID 12414990.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Festenstein R, Pagakis SN, Hiragami K; et al. (2003). "Modulation of heterochromatin protein 1 dynamics in primary Mammalian cells". Science. 299 (5607): 719–21. doi:10.1126/science.1078694. PMID 12560554.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• CBX1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.