CEBPD
| CCAAT/enhancer binding protein (C/EBP), delta | |||||||||||
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| Identifiers | |||||||||||
| Symbols | CEBPD ; C/EBP-delta; CELF; CRP3; NF-IL6-beta | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 3808 | ||||||||||
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| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
CCAAT/enhancer binding protein (C/EBP), delta, also known as CEBPD, is a human gene.
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.[1]
See also
References
Further reading
- Sladek FM, Darnell JE (1992). "Mechanisms of liver-specific gene expression". Curr. Opin. Genet. Dev. 2 (2): 256–9. PMID 1638120.
- Kinoshita S, Akira S, Kishimoto T (1992). "A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1473–6. PMID 1741402.
- Cao Z, Umek RM, McKnight SL (1991). "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells". Genes Dev. 5 (9): 1538–52. PMID 1840554.
- Williams SC, Cantwell CA, Johnson PF (1991). "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro". Genes Dev. 5 (9): 1553–67. PMID 1884998.
- Nagulapalli S, Pongubala JM, Atchison ML (1995). "Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3)". J. Immunol. 155 (9): 4330–8. PMID 7594592.
- Wood S, Schertzer M, Yaremko ML (1995). "Sequence identity locates CEBPD and FGFR1 to mapped human loci within proximal 8p". Cytogenet. Cell Genet. 70 (3–4): 188–91. PMID 7789168.
- Cleutjens CB, van Eekelen CC, van Dekken H; et al. (1993). "The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization". Genomics. 16 (2): 520–3. PMID 8314590.
- Chen PL, Riley DJ, Chen Y, Lee WH (1997). "Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs". Genes Dev. 10 (21): 2794–804. PMID 8946919.
- Xia C, Cheshire JK, Patel H, Woo P (1998). "Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes". Int. J. Biochem. Cell Biol. 29 (12): 1525–39. PMID 9570146.
- Zhu Y, Saunders MA, Yeh H; et al. (2002). "Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins". J. Biol. Chem. 277 (9): 6923–8. doi:10.1074/jbc.M108075200. PMID 11741938.
- Angeloni D, Lee JD, Johnson BE; et al. (2002). "C306A single nucleotide polymorphism in the human CEBPD gene that maps at 8p11.1-p11.2". Mol. Cell. Probes. 15 (6): 395–7. doi:10.1006/mcpr.2001.0377. PMID 11851384.
- Gao H, Parkin S, Johnson PF, Schwartz RC (2002). "C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters". J. Biol. Chem. 277 (41): 38827–37. doi:10.1074/jbc.M206224200. PMID 12177065.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Dearth LR, DeWille J (2003). "Posttranscriptional and posttranslational regulation of C/EBP delta in G0 growth-arrested mammary epithelial cells". J. Biol. Chem. 278 (13): 11246–55. doi:10.1074/jbc.M207930200. PMID 12554732.
- Milde-Langosch K, Löning T, Bamberger AM (2003). "Expression of the CCAAT/enhancer-binding proteins C/EBPalpha, C/EBPbeta and C/EBPdelta in breast cancer: correlations with clinicopathologic parameters and cell-cycle regulatory proteins". Breast Cancer Res. Treat. 79 (2): 175–85. PMID 12825852.
- Kovács KA, Steinmann M, Magistretti PJ; et al. (2003). "CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation". J. Biol. Chem. 278 (38): 36959–65. doi:10.1074/jbc.M303147200. PMID 12857754.
- Chen YW, Hubal MJ, Hoffman EP; et al. (2004). "Molecular responses of human muscle to eccentric exercise". J. Appl. Physiol. 95 (6): 2485–94. doi:10.1152/japplphysiol.01161.2002. PMID 12937035.
- Li R, Strohmeyer R, Liang Z; et al. (2004). "CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease". Neurobiol. Aging. 25 (8): 991–9. doi:10.1016/j.neurobiolaging.2003.10.016. PMID 15212823.
- Sivko GS, Sanford DC, Dearth LD; et al. (2005). "CCAAT/Enhancer binding protein delta (c/EBPdelta) regulation and expression in human mammary epithelial cells: II. Analysis of activating signal transduction pathways, transcriptional, post-transcriptional, and post-translational control". J. Cell. Biochem. 93 (4): 844–56. doi:10.1002/jcb.20224. PMID 15389878.
External links
- CEBPD+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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