ELK4
| ELK4, ETS-domain protein (SRF accessory protein 1) | |||||||||||||
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 PDB rendering based on 1bc7. | |||||||||||||
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| Symbols | ELK4 ; SAP1 | ||||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 1492 | ||||||||||||
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| Species | Human | Mouse | |||||||||||
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ELK4, ETS-domain protein (SRF accessory protein 1), also known as ELK4, is a human gene.[1]
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene.[1]
References
Further reading
- Sharrocks AD, Brown AL, Ling Y, Yates PR (1998). "The ETS-domain transcription factor family". Int. J. Biochem. Cell Biol. 29 (12): 1371–87. PMID 9570133.
- Wasylyk B, Hagman J, Gutierrez-Hartmann A (1998). "Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway". Trends Biochem. Sci. 23 (6): 213–6. PMID 9644975.
- Dalton S, Treisman R (1992). "Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element". Cell. 68 (3): 597–612. PMID 1339307.
- Price MA, Rogers AE, Treisman R (1995). "Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET)". EMBO J. 14 (11): 2589–601. PMID 7540136.
- Adams MD, Kerlavage AR, Fleischmann RD; et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence". Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
- Shipley J, Sheer D, Dalton S; et al. (1995). "Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively". Genomics. 23 (3): 710–1. doi:10.1006/geno.1994.1564. PMID 7851904.
- Dalton S, Treisman R (1994). "Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element". Cell. 76 (2): 411. PMID 8293474.
- Giovane A, Sobieszczuk P, Mignon C; et al. (1996). "Locations of the ets subfamily members net, elk1, and sap1 (ELK3, ELK1, and ELK4) on three homologous regions of the mouse and human genomes". Genomics. 29 (3): 769–72. doi:10.1006/geno.1995.9938. PMID 8575773.
- Janknecht R, Hunter T (1997). "Activation of the Sap-1a transcription factor by the c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase". J. Biol. Chem. 272 (7): 4219–24. PMID 9020136.
- Janknecht R, Hunter T (1997). "Convergence of MAP kinase pathways on the ternary complex factor Sap-1a". EMBO J. 16 (7): 1620–7. doi:10.1093/emboj/16.7.1620. PMID 9130707.
- Stein B, Yang MX, Young DB; et al. (1997). "p38-2, a novel mitogen-activated protein kinase with distinct properties". J. Biol. Chem. 272 (31): 19509–17. PMID 9235954.
- Mo Y, Vaessen B, Johnston K, Marmorstein R (1998). "Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins". Mol. Cell. 2 (2): 201–12. PMID 9734357.
- Yates PR, Atherton GT, Deed RW; et al. (1999). "Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors". EMBO J. 18 (4): 968–76. doi:10.1093/emboj/18.4.968. PMID 10022839.
- Kamakura S, Moriguchi T, Nishida E (1999). "Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus". J. Biol. Chem. 274 (37): 26563–71. PMID 10473620.
- Chai Y, Chipitsyna G, Cui J; et al. (2001). "c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells". Oncogene. 20 (11): 1357–67. doi:10.1038/sj.onc.1204256. PMID 11313879.
- Hassler M, Richmond TJ (2001). "The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex". EMBO J. 20 (12): 3018–28. doi:10.1093/emboj/20.12.3018. PMID 11406578.
- Mo Y, Ho W, Johnston K, Marmorstein R (2002). "Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex". J. Mol. Biol. 314 (3): 495–506. doi:10.1006/jmbi.2001.5138. PMID 11846562.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
External links
- ELK4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.