EN1 (gene)

Engrailed homeobox 1
Identifiers
Symbols	EN1 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 50663
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Engrailed homeobox 1, also known as EN1, is a human gene.

Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system.

Further reading

• Logan C, Hanks MC, Noble-Topham S; et al. (1993). "Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions". Dev. Genet. 13 (5): 345–58. doi:10.1002/dvg.1020130505. PMID 1363401.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Logan C, Willard HF, Rommens JM, Joyner AL (1989). "Chromosomal localization of the human homeo box-containing genes, EN1 and EN2". Genomics. 4 (2): 206–9. PMID 2567700.CS1 maint: Multiple names: authors list (link)
• Kozmik Z, Sure U, Rüedi D; et al. (1995). "Deregulated expression of PAX5 in medulloblastoma". Proc. Natl. Acad. Sci. U.S.A. 92 (12): 5709–13. PMID 7777574.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Köhler A, Logan C, Joyner AL, Muenke M (1993). "Regional assignment of the human homeobox-containing gene EN1 to chromosome 2q13-q21". Genomics. 15 (1): 233–5. doi:10.1006/geno.1993.1045. PMID 8094370.CS1 maint: Multiple names: authors list (link)
• Loomis CA, Harris E, Michaud J; et al. (1996). "The mouse Engrailed-1 gene and ventral limb patterning". Nature. 382 (6589): 360–3. doi:10.1038/382360a0. PMID 8684466.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Joliot A, Trembleau A, Raposo G; et al. (1997). "Association of Engrailed homeoproteins with vesicles presenting caveolae-like properties". Development. 124 (10): 1865–75. PMID 9169834.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mikkola I, Bruun JA, Holm T, Johansen T (2001). "Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins". J. Biol. Chem. 276 (6): 4109–18. doi:10.1074/jbc.M008882200. PMID 11069920.CS1 maint: Multiple names: authors list (link)
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.CS1 maint: Multiple names: authors list (link)
• Schaefer LK, Wang S, Schaefer TS (2001). "Functional interaction of Jun and homeodomain proteins". J. Biol. Chem. 276 (46): 43074–82. doi:10.1074/jbc.M102552200. PMID 11551904.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hori Y, Gu X, Xie X, Kim SK (2006). "Differentiation of insulin-producing cells from human neural progenitor cells". PLoS Med. 2 (4): e103. doi:10.1371/journal.pmed.0020103. PMID 15839736.CS1 maint: Multiple names: authors list (link)
• Bachar-Dahan L, Goltzmann J, Yaniv A, Gazit A (2006). "Engrailed-1 negatively regulates beta-catenin transcriptional activity by destabilizing beta-catenin via a glycogen synthase kinase-3beta-independent pathway". Mol. Biol. Cell. 17 (6): 2572–80. doi:10.1091/mbc.E06-01-0052. PMID 16571670.CS1 maint: Multiple names: authors list (link)
• Atit R, Sgaier SK, Mohamed OA; et al. (2006). "Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse". Dev. Biol. 296 (1): 164–76. doi:10.1016/j.ydbio.2006.04.449. PMID 16730693.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• EN1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.