EPAS1

Endothelial PAS domain protein 1
PDB rendering based on 1p97.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1p97​, 2a24​
Identifiers
Symbols	EPAS1 ; HIF2A; HLF; MOP2; PASD2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1095
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Endothelial PAS domain protein 1, also known as EPAS1, is a human gene.

Further reading

• Brahimi-Horn MC, Pouysségur J (2005). "The hypoxia-inducible factor and tumor progression along the angiogenic pathway". Int. Rev. Cytol. 242: 157–213. doi:10.1016/S0074-7696(04)42004-X. PMID 15598469.
• Haase VH (2006). "Hypoxia-inducible factors in the kidney". Am. J. Physiol. Renal Physiol. 291 (2): F271–81. doi:10.1152/ajprenal.00071.2006. PMID 16554418.
• Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tian H, McKnight SL, Russell DW (1997). "Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells". Genes Dev. 11 (1): 72–82. PMID 9000051.CS1 maint: Multiple names: authors list (link)
• Hogenesch JB, Chan WK, Jackiw VH; et al. (1997). "Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway". J. Biol. Chem. 272 (13): 8581–93. PMID 9079689.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. PMID 9110174.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ema M, Taya S, Yokotani N; et al. (1997). "A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4273–8. PMID 9113979.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hogenesch JB, Gu YZ, Jain S, Bradfield CA (1998). "The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors". Proc. Natl. Acad. Sci. U.S.A. 95 (10): 5474–9. PMID 9576906.CS1 maint: Multiple names: authors list (link)
• Takahata S, Sogawa K, Kobayashi A; et al. (1998). "Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock". Biochem. Biophys. Res. Commun. 248 (3): 789–94. doi:10.1006/bbrc.1998.9012. PMID 9704006.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ema M, Hirota K, Mimura J; et al. (1999). "Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300". EMBO J. 18 (7): 1905–14. doi:10.1093/emboj/18.7.1905. PMID 10202154.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cockman ME, Masson N, Mole DR; et al. (2000). "Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein". J. Biol. Chem. 275 (33): 25733–41. doi:10.1074/jbc.M002740200. PMID 10823831.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maemura K, de la Monte SM, Chin MT; et al. (2001). "CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression". J. Biol. Chem. 275 (47): 36847–51. doi:10.1074/jbc.C000629200. PMID 11018023.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Luo JC, Shibuya M (2001). "A variant of nuclear localization signal of bipartite-type is required for the nuclear translocation of hypoxia inducible factors (1alpha, 2alpha and 3alpha)". Oncogene. 20 (12): 1435–44. doi:10.1038/sj.onc.1204228. PMID 11313887.
• Woods SL, Whitelaw ML (2002). "Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors". J. Biol. Chem. 277 (12): 10236–43. doi:10.1074/jbc.M110752200. PMID 11782478.
• Lando D, Peet DJ, Whelan DA; et al. (2002). "Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch". Science. 295 (5556): 858–61. doi:10.1126/science.1068592. PMID 11823643.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mole DR, Pugh CW, Ratcliffe PJ, Maxwell PH (2002). "Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex". Adv. Enzyme Regul. 42: 333–47. PMID 12123724.CS1 maint: Multiple names: authors list (link)
• Sivridis E, Giatromanolaki A, Gatter KC; et al. (2002). "Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma". Cancer. 95 (5): 1055–63. doi:10.1002/cncr.10774. PMID 12209691.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Elvert G, Kappel A, Heidenreich R; et al. (2003). "Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)". J. Biol. Chem. 278 (9): 7520–30. doi:10.1074/jbc.M211298200. PMID 12464608.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sang N, Stiehl DP, Bohensky J; et al. (2003). "MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300". J. Biol. Chem. 278 (16): 14013–9. doi:10.1074/jbc.M209702200. PMID 12588875.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• EPAS1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.