Estrogen-related receptor beta

Estrogen-related receptor beta
File:PBB Protein ESRRB image.jpg PDB rendering based on 1lo1.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1lo1​
Identifiers
Symbols	ESRRB ; ERR2; ERRb; ERRbeta; ERRbeta-2; ESRL2; NR3B2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 69108
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Estrogen-related receptor beta (ERR-beta), also known as NR3B2 (nuclear receptor subfamily 3, group B, member 2), is a nuclear receptor which is encoded by the gene ESRRB (EStrogen Related Receptor Beta).

This gene encodes a protein with sequence similarity to the estrogen receptor, a member of nuclear hormone receptor family of steroid hormone receptors. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development.

Further reading

• Giguère V, Yang N, Segui P, Evans RM (1988). "Identification of a new class of steroid hormone receptors". Nature. 331 (6151): 91–4. doi:10.1038/331091a0. PMID 3267207.CS1 maint: Multiple names: authors list (link)
• Sladek R, Beatty B, Squire J; et al. (1998). "Chromosomal mapping of the human and murine orphan receptors ERRalpha (ESRRA) and ERRbeta (ESRRB) and identification of a novel human ERRalpha-related pseudogene". Genomics. 45 (2): 320–6. doi:10.1006/geno.1997.4939. PMID 9344655.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Enmark E, Pelto-Huikko M, Grandien K; et al. (1998). "Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern". J. Clin. Endocrinol. Metab. 82 (12): 4258–65. PMID 9398750.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen F, Zhang Q, McDonald T; et al. (1999). "Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR". Gene. 228 (1–2): 101–9. PMID 10072763.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xie W, Hong H, Yang NN; et al. (2000). "Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2". Mol. Endocrinol. 13 (12): 2151–62. PMID 10598588.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Heilig R, Eckenberg R, Petit JL; et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gearhart MD, Holmbeck SM, Evans RM; et al. (2003). "Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition". J. Mol. Biol. 327 (4): 819–32. PMID 12654265.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kruijver FP, Balesar R, Espila AM; et al. (2003). "Estrogen-receptor-beta distribution in the human hypothalamus: similarities and differences with ER alpha distribution". J. Comp. Neurol. 466 (2): 251–77. doi:10.1002/cne.10899. PMID 14528452.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stossi F, Barnett DH, Frasor J; et al. (2004). "Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ERbeta in human osteosarcoma cells: distinct and common target genes for these receptors". Endocrinology. 145 (7): 3473–86. doi:10.1210/en.2003-1682. PMID 15033914.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Verdier-Sevrain S, Yaar M, Cantatore J; et al. (2005). "Estradiol induces proliferation of keratinocytes via a receptor mediated mechanism". FASEB J. 18 (11): 1252–4. doi:10.1096/fj.03-1088fje. PMID 15208259.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Smith LH, Coats SR, Qin H; et al. (2005). "Differential and opposing regulation of PAI-1 promoter activity by estrogen receptor alpha and estrogen receptor beta in endothelial cells". Circ. Res. 95 (3): 269–75. doi:10.1161/01.RES.0000136521.70093.f1. PMID 15217907.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu PY, Christian RC, Ruan M; et al. (2005). "Correlating androgen and estrogen steroid receptor expression with coronary calcification and atherosclerosis in men without known coronary artery disease". J. Clin. Endocrinol. Metab. 90 (2): 1041–6. doi:10.1210/jc.2004-1211. PMID 15536156.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cheung CP, Yu S, Wong KB; et al. (2005). "Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues". J. Clin. Endocrinol. Metab. 90 (3): 1830–44. doi:10.1210/jc.2004-1421. PMID 15598686.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhou W, Liu Z, Wu J; et al. (2006). "Identification and characterization of two novel splicing isoforms of human estrogen-related receptor beta". J. Clin. Endocrinol. Metab. 91 (2): 569–79. doi:10.1210/jc.2004-1957. PMID 16332939.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.