FOSL1

FOS-like antigen 1
Identifiers
Symbols	FOSL1 ; FRA1; fra-1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3967
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

FOS-like antigen 1, also known as FOSL1, is a human gene.

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.

See also

• AP-1 (transcription factor)

Further reading

• Herdegen T, Leah JD (1999). "Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins". Brain Res. Brain Res. Rev. 28 (3): 370–490. PMID 9858769.
• Reddy SP, Mossman BT (2002). "Role and regulation of activator protein-1 in toxicant-induced responses of the lung". Am. J. Physiol. Lung Cell Mol. Physiol. 283 (6): L1161–78. doi:10.1152/ajplung.00140.2002. PMID 12424143.
• Matsui M, Tokuhara M, Konuma Y; et al. (1990). "Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation". Oncogene. 5 (3): 249–55. PMID 2107490.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Tsuchiya H, Fujii M, Niki T; et al. (1993). "Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals". J. Virol. 67 (12): 7001–7. PMID 8230424.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sinke RJ, Tanigami A, Nakamura Y, Geurts van Kessel A (1994). "Reverse mapping of the gene encoding the human fos-related antigen-1 (fra-1) within chromosome band 11q13". Genomics. 18 (1): 165. PMID 8276409.CS1 maint: Multiple names: authors list (link)
• Courseaux A, Grosgeorge J, Gaudray P; et al. (1997). "Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1)". Genomics. 37 (3): 354–65. PMID 8938448.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Arts J, Herr I, Lansink M; et al. (1997). "Cell-type specific DNA-protein interactions at the tissue-type plasminogen activator promoter in human endothelial and HeLa cells in vivo and in vitro". Nucleic Acids Res. 25 (2): 311–7. PMID 9016559.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pognonec P, Boulukos KE, Aperlo C; et al. (1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity". Oncogene. 14 (17): 2091–8. doi:10.1038/sj.onc.1201046. PMID 9160889.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Smith CM, Ma NS, Nowak NJ; et al. (1997). "A 3-Mb contig from D11S987 to MLK3, a gene-rich region in 11q13". Genome Res. 7 (8): 835–42. PMID 9267807.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Puntschart A, Wey E, Jostarndt K; et al. (1998). "Expression of fos and jun genes in human skeletal muscle after exercise". Am. J. Physiol. 274 (1 Pt 1): C129–37. PMID 9458721.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Finzer P, Soto U, Delius H; et al. (2000). "Differential transcriptional regulation of the monocyte-chemoattractant protein-1 (MCP-1) gene in tumorigenic and non-tumorigenic HPV 18 positive cells: the role of the chromatin structure and AP-1 composition". Oncogene. 19 (29): 3235–44. doi:10.1038/sj.onc.1203643. PMID 10918580.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Udalova IA, Kwiatkowski D (2001). "Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region". Biochem. Biophys. Res. Commun. 289 (1): 25–33. doi:10.1006/bbrc.2001.5929. PMID 11708771.
• Jardine H, MacNee W, Donaldson K, Rahman I (2002). "Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1". J. Biol. Chem. 277 (24): 21158–66. doi:10.1074/jbc.M112145200. PMID 11912197.CS1 maint: Multiple names: authors list (link)
• Wang HL, Wang J, Xiao SY; et al. (2002). "Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin". Int. J. Cancer. 101 (4): 301–10. doi:10.1002/ijc.10630. PMID 12209953.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bergman MR, Cheng S, Honbo N; et al. (2003). "A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers". Biochem. J. 369 (Pt 3): 485–96. doi:10.1042/BJ20020707. PMID 12371906.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• FOSL1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.