FOXO4

Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7
PDB rendering based on 1e17.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1e17​
Identifiers
Symbols	MLLT7 ; AFX; AFX1; FOXO4; MGC120490
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4342
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7, also known as MLLT7, is a human gene.

See also

• FOX proteins

Further reading

• Parry P, Wei Y, Evans G (1995). "Cloning and characterization of the t(X;11) breakpoint from a leukemic cell line identify a new member of the forkhead gene family". Genes Chromosomes Cancer. 11 (2): 79–84. PMID 7529552.CS1 maint: Multiple names: authors list (link)
• Borkhardt A, Repp R, Haas OA; et al. (1997). "Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23)". Oncogene. 14 (2): 195–202. doi:10.1038/sj.onc.1200814. PMID 9010221.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Peters U, Haberhausen G, Kostrzewa M; et al. (1997). "AFX1 and p54nrb: fine mapping, genomic structure, and exclusion as candidate genes of X-linked dystonia parkinsonism". Hum. Genet. 100 (5–6): 569–72. PMID 9341872.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kops GJ, de Ruiter ND, De Vries-Smits AM; et al. (1999). "Direct control of the Forkhead transcription factor AFX by protein kinase B.". Nature. 398 (6728): 630–4. doi:10.1038/19328. PMID 10217147.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takaishi H, Konishi H, Matsuzaki H; et al. (1999). "Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B.". Proc. Natl. Acad. Sci. U.S.A. 96 (21): 11836–41. PMID 10518537.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Medema RH, Kops GJ, Bos JL, Burgering BM (2000). "AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1". Nature. 404 (6779): 782–7. doi:10.1038/35008115. PMID 10783894.CS1 maint: Multiple names: authors list (link)
• Furuyama T, Nakazawa T, Nakano I, Mori N (2001). "Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues". Biochem. J. 349 (Pt 2): 629–34. PMID 10880363.CS1 maint: Multiple names: authors list (link)
• Weigelt J, Climent I, Dahlman-Wright K, Wikström M (2000). "1H, 13C and 15N resonance assignments of the DNA binding domain of the human forkhead transcription factor AFX". J. Biomol. NMR. 17 (2): 181–2. PMID 10921784.CS1 maint: Multiple names: authors list (link)
• Nasrin N, Ogg S, Cahill CM; et al. (2000). "DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells". Proc. Natl. Acad. Sci. U.S.A. 97 (19): 10412–7. doi:10.1073/pnas.190326997. PMID 10973497.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brownawell AM, Kops GJ, Macara IG, Burgering BM (2001). "Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX". Mol. Cell. Biol. 21 (10): 3534–46. doi:10.1128/MCB.21.10.3534-3546.2001. PMID 11313479.CS1 maint: Multiple names: authors list (link)
• Weigelt J, Climent I, Dahlman-Wright K, Wikström M (2001). "Solution structure of the DNA binding domain of the human forkhead transcription factor AFX (FOXO4)". Biochemistry. 40 (20): 5861–9. PMID 11352721.CS1 maint: Multiple names: authors list (link)
• Schuur ER, Loktev AV, Sharma M; et al. (2001). "Ligand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor family". J. Biol. Chem. 276 (36): 33554–60. doi:10.1074/jbc.M105555200. PMID 11435445.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• De Ruiter ND, Burgering BM, Bos JL (2001). "Regulation of the Forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451". Mol. Cell. Biol. 21 (23): 8225–35. doi:10.1128/MCB.21.23.8225-8235.2001. PMID 11689711.CS1 maint: Multiple names: authors list (link)
• Tang TT, Dowbenko D, Jackson A; et al. (2002). "The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor". J. Biol. Chem. 277 (16): 14255–65. doi:10.1074/jbc.M110901200. PMID 11777915.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang Z, Whelan J, Babb R, Bowen BR (2002). "An mRNA splice variant of the AFX gene with altered transcriptional activity". J. Biol. Chem. 277 (10): 8068–75. doi:10.1074/jbc.M106091200. PMID 11779849.CS1 maint: Multiple names: authors list (link)
• Kops GJ, Medema RH, Glassford J; et al. (2002). "Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors". Mol. Cell. Biol. 22 (7): 2025–36. PMID 11884591.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• So CW, Cleary ML (2002). "MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function". Mol. Cell. Biol. 22 (18): 6542–52. PMID 12192052.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tang TT, Lasky LA (2003). "The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanism". J. Biol. Chem. 278 (32): 30125–35. doi:10.1074/jbc.M302042200. PMID 12761217.
• Crossley LJ (2003). "Neutrophil activation by fMLP regulates FOXO (forkhead) transcription factors by multiple pathways, one of which includes the binding of FOXO to the survival factor Mcl-1". J. Leukoc. Biol. 74 (4): 583–92. doi:10.1189/jlb.0103020. PMID 12960271.

External links

• MLLT7+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.