HES1
| Hairy and enhancer of split 1, (Drosophila) | |||||||||||
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| Symbols | HES1 ; FLJ20408; HES-1; HHL; HRY | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 38067 | ||||||||||
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| Species | Human | Mouse | |||||||||
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| RefSeq (protein) | n/a | n/a | |||||||||
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Hairy and enhancer of split 1, (Drosophila), also known as HES1, is a human gene.[1]
This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.[1]
References
Further reading
- Takebayashi K, Sasai Y, Sakai Y; et al. (1994). "Structure, chromosomal locus, and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the multiple N box elements". J. Biol. Chem. 269 (7): 5150–6. PMID 7906273.
- Feder JN, Li L, Jan LY, Jan YN (1994). "Genomic cloning and chromosomal localization of HRY, the human homolog to the Drosophila segmentation gene, hairy". Genomics. 20 (1): 56–61. doi:10.1006/geno.1994.1126. PMID 8020957.
- Grbavec D, Stifani S (1996). "Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif". Biochem. Biophys. Res. Commun. 223 (3): 701–5. doi:10.1006/bbrc.1996.0959. PMID 8687460.
- Ström A, Castella P, Rockwood J; et al. (1998). "Mediation of NGF signaling by post-translational inhibition of HES-1, a basic helix-loop-helix repressor of neuronal differentiation". Genes Dev. 11 (23): 3168–81. PMID 9389649.
- Votruba M, Payne A, Moore AT, Bhattacharya SS (1998). "Dominant optic atrophy: exclusion and fine genetic mapping of the candidate gene, HRY". Mamm. Genome. 9 (10): 784–7. PMID 9745030.
- Bae S, Bessho Y, Hojo M, Kageyama R (2000). "The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation". Development. 127 (13): 2933–43. PMID 10851137.
- Yao J, Lai E, Stifani S (2001). "The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription". Mol. Cell. Biol. 21 (6): 1962–72. doi:10.1128/MCB.21.6.1962-1972.2001. PMID 11238932.
- Iso T, Sartorelli V, Poizat C; et al. (2001). "HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling". Mol. Cell. Biol. 21 (17): 6080–9. PMID 11486045.
- Dintilhac A, Bernués J (2002). "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences". J. Biol. Chem. 277 (9): 7021–8. doi:10.1074/jbc.M108417200. PMID 11748221.
- Jögi A, Persson P, Grynfeld A; et al. (2002). "Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation". J. Biol. Chem. 277 (11): 9118–26. doi:10.1074/jbc.M107713200. PMID 11756408.
- Kunisato A, Chiba S, Nakagami-Yamaguchi E; et al. (2003). "HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo". Blood. 101 (5): 1777–83. doi:10.1182/blood-2002-07-2051. PMID 12406868.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Takata T, Ishikawa F (2003). "Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression". Biochem. Biophys. Res. Commun. 301 (1): 250–7. PMID 12535671.
- Gratton MO, Torban E, Jasmin SB; et al. (2003). "Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms". Mol. Cell. Biol. 23 (19): 6922–35. PMID 12972610.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Thomsen JS, Kietz S, Ström A, Gustafsson JA (2004). "HES-1, a novel target gene for the aryl hydrocarbon receptor". Mol. Pharmacol. 65 (1): 165–71. doi:10.1124/mol.65.1.165. PMID 14722248.
- Kamakura S, Oishi K, Yoshimatsu T; et al. (2004). "Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling". Nat. Cell Biol. 6 (6): 547–54. doi:10.1038/ncb1138. PMID 15156153.
- Persson P, Stockhausen MT, Påhlman S, Axelson H (2005). "Ubiquilin-1 is a novel HASH-1-complexing protein that regulates levels of neuronal bHLH transcription factors in human neuroblastoma cells". Int. J. Oncol. 25 (5): 1213–21. PMID 15492808.
- Aguilera C, Hoya-Arias R, Haegeman G; et al. (2004). "Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repression". Proc. Natl. Acad. Sci. U.S.A. 101 (47): 16537–42. doi:10.1073/pnas.0404429101. PMID 15536134.
- Fryer CJ, White JB, Jones KA (2005). "Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover". Mol. Cell. 16 (4): 509–20. doi:10.1016/j.molcel.2004.10.014. PMID 15546612.
External links
- HES1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.