HIVEP1

Human immunodeficiency virus type I enhancer binding protein 1
PDB rendering based on 1bbo.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1bbo​, 3znf​, 4znf​
Identifiers
Symbols	HIVEP1 ; MBP-1; CIRIP; CRYBP1; PRDII-BF1; ZNF40
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1596
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Human immunodeficiency virus type I enhancer binding protein 1, also known as HIVEP1, is a human gene.

Members of the ZAS family, such as ZAS1 (HIVEP1), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM]

Further reading

• Omichinski JG, Clore GM, Robien M; et al. (1992). "High-resolution solution structure of the double Cys2His2 zinc finger from the human enhancer binding protein MBP-1". Biochemistry. 31 (16): 3907–17. PMID 1567844.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakamura T, Donovan DM, Hamada K; et al. (1990). "Regulation of the mouse alpha A-crystallin gene: isolation of a cDNA encoding a protein that binds to a cis sequence motif shared with the major histocompatibility complex class I gene and other genes". Mol. Cell. Biol. 10 (7): 3700–8. PMID 1694016.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Muchardt C, Seeler JS, Nirula A; et al. (1992). "Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products". J. Virol. 66 (1): 244–50. PMID 1727488.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gaynor RB, Muchardt C, Diep A; et al. (1991). "Localization of the zinc finger DNA-binding protein HIV-EP1/MBP-1/PRDII-BF1 to human chromosome 6p22.3-p24". Genomics. 9 (4): 758–61. PMID 2037300.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fan CM, Maniatis T (1990). "A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence". Genes Dev. 4 (1): 29–42. PMID 2106471.
• Baldwin AS, LeClair KP, Singh H, Sharp PA (1990). "A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompatibility complex and kappa immunoglobulin genes". Mol. Cell. Biol. 10 (4): 1406–14. PMID 2108316.CS1 maint: Multiple names: authors list (link)
• Omichinski JG, Clore GM, Appella E; et al. (1991). "High-resolution three-dimensional structure of a single zinc finger from a human enhancer binding protein in solution". Biochemistry. 29 (40): 9324–34. PMID 2248949.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maekawa T, Sakura H, Sudo T, Ishii S (1989). "Putative metal finger structure of the human immunodeficiency virus type 1 enhancer binding protein HIV-EP1". J. Biol. Chem. 264 (25): 14591–3. PMID 2504707.CS1 maint: Multiple names: authors list (link)
• Otsuka M, Fujita M, Aoki T; et al. (1995). "Novel zinc chelators with dual activity in the inhibition of the kappa B site-binding proteins HIV-EP1 and NF-kappa B.". J. Med. Chem. 38 (17): 3264–70. PMID 7650680.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Seeler JS, Muchardt C, Suessle A, Gaynor RB (1994). "Transcription factor PRDII-BF1 activates human immunodeficiency virus type 1 gene expression". J. Virol. 68 (2): 1002–9. PMID 8289330.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Colland F, Jacq X, Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wissmüller S, Kosian T, Wolf M; et al. (2006). "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors". Nucleic Acids Res. 34 (6): 1735–44. doi:10.1093/nar/gkl105. PMID 16582099.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lim J, Hao T, Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• HIVEP1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.