HOXA13

Homeobox A13
Identifiers
Symbols	HOXA13 ; HOX1; HOX1J
External IDs	Template:OMIM5 Template:MGI HomoloGene: 73882
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Homeobox A13, also known as HOXA13, is a human gene.

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome.

See also

• Homeobox

Further reading

• Goodman FR, Scambler PJ (2001). "Human HOX gene mutations". Clin. Genet. 59 (1): 1–11. PMID 11206481.
• Utsch B, Becker K, Brock D; et al. (2002). "A novel stable polyalanine [poly(A)] expansion in the HOXA13 gene associated with hand-foot-genital syndrome: proper function of poly(A)-harbouring transcription factors depends on a critical repeat length?". Hum. Genet. 110 (5): 488–94. doi:10.1007/s00439-002-0712-8. PMID 12073020.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scott MP (1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. PMID 1358459.
• McAlpine PJ, Shows TB (1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. PMID 1973146.
• Acampora D, D'Esposito M, Faiella A; et al. (1990). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402. PMID 2574852.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Apiou F, Flagiello D, Cillo C; et al. (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–5. PMID 8646877.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mortlock DP, Innis JW (1997). "Mutation of HOXA13 in hand-foot-genital syndrome". Nat. Genet. 15 (2): 179–80. doi:10.1038/ng0297-179. PMID 9020844.
• "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. PMID 9847074.
• Post LC, Innis JW (1999). "Infertility in adult hypodactyly mice is associated with hypoplasia of distal reproductive structures". Biol. Reprod. 61 (6): 1402–8. PMID 10569982.
• de Stanchina E, Gabellini D, Norio P; et al. (2000). "Selection of homeotic proteins for binding to a human DNA replication origin". J. Mol. Biol. 299 (3): 667–80. doi:10.1006/jmbi.2000.3782. PMID 10835276.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Goodman FR, Bacchelli C, Brady AF; et al. (2000). "Novel HOXA13 mutations and the phenotypic spectrum of hand-foot-genital syndrome". Am. J. Hum. Genet. 67 (1): 197–202. PMID 10839976.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhao Y, Potter SS (2001). "Functional specificity of the Hoxa13 homeobox". Development. 128 (16): 3197–207. PMID 11688568.
• Fujino T, Suzuki A, Ito Y; et al. (2002). "Single-translocation and double-chimeric transcripts: detection of NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15)". Blood. 99 (4): 1428–33. PMID 11830496.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kosaki K, Kosaki R, Suzuki T; et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Innis JW, Goodman FR, Bacchelli C; et al. (2002). "A HOXA13 allele with a missense mutation in the homeobox and a dinucleotide deletion in the promoter underlies Guttmacher syndrome". Hum. Mutat. 19 (5): 573–4. doi:10.1002/humu.9036. PMID 11968094.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Taketani T, Taki T, Ono R; et al. (2002). "The chromosome translocation t(7;11)(p15;p15) in acute myeloid leukemia results in fusion of the NUP98 gene with a HOXA cluster gene, HOXA13, but not HOXA9". Genes Chromosomes Cancer. 34 (4): 437–43. doi:10.1002/gcc.10077. PMID 12112533.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Debeer P, Bacchelli C, Scambler PJ; et al. (2002). "Severe digital abnormalities in a patient heterozygous for both a novel missense mutation in HOXD13 and a polyalanine tract expansion in HOXA13". J. Med. Genet. 39 (11): 852–6. PMID 12414828.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• HOXA13+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.