HOXA4

Homeobox A4
Identifiers
Symbols	HOXA4 ; HOX1; HOX1D
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37583
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Homeobox A4, also known as HOXA4, is a human gene.

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation.

See also

• Homeobox

Further reading

• Scott MP (1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. PMID 1358459.
• Buettner R, Yim SO, Hong YS; et al. (1991). "Alteration of homeobox gene expression by N-ras transformation of PA-1 human teratocarcinoma cells". Mol. Cell. Biol. 11 (7): 3573–83. PMID 1675427.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McAlpine PJ, Shows TB (1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. PMID 1973146.
• Peverali FA, D'Esposito M, Acampora D; et al. (1991). "Expression of HOX homeogenes in human neuroblastoma cell culture lines". Differentiation. 45 (1): 61–9. PMID 1981366.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ferguson-Smith AC, Fienberg A, Ruddle FH (1989). "Isolation, chromosomal localization, and nucleotide sequence of the human HOX 1.4 homeobox". Genomics. 5 (2): 250–8. PMID 2571574.CS1 maint: Multiple names: authors list (link)
• Boncinelli E, Acampora D, Pannese M; et al. (1990). "Organization of human class I homeobox genes". Genome. 31 (2): 745–56. PMID 2576652.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Verlinsky Y, Morozov G, Gindilis V; et al. (1995). "Homeobox gene expression in human oocytes and preembryos". Mol. Reprod. Dev. 41 (2): 127–32. doi:10.1002/mrd.1080410202. PMID 7654365.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Apiou F, Flagiello D, Cillo C; et al. (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–5. PMID 8646877.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kuliev A, Kukharenko V, Morozov G; et al. (1996). "Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies". J. Assist. Reprod. Genet. 13 (2): 177–81. PMID 8688592.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Duluc I, Lorentz O, Fritsch C; et al. (1997). "Changing intestinal connective tissue interactions alters homeobox gene expression in epithelial cells". J. Cell. Sci. 110 ( Pt 11): 1317–24. PMID 9202392.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stelnicki EJ, Kömüves LG, Kwong AO; et al. (1998). "HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development". J. Invest. Dermatol. 110 (2): 110–5. doi:10.1046/j.1523-1747.1998.00092.x. PMID 9457903.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Verlinsky Y, Morozov G, Verlinsky O; et al. (1998). "Isolation of cDNA libraries from individual human preimplantation embryos". Mol. Hum. Reprod. 4 (6): 571–5. PMID 9665340.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. PMID 9847074.
• Kosaki K, Kosaki R, Suzuki T; et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Larramendy ML, Niini T, Elonen E; et al. (2003). "Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis". Haematologica. 87 (6): 569–77. PMID 12031912.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Méchine-Neuville A, Lefebvre O, Bellocq JP; et al. (2003). "[Increased expression of HOXA9 gene in Hirschsprung disease]". Gastroenterol. Clin. Biol. 26 (12): 1110–7. PMID 12520199.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strathdee G, Sim A, Parker A; et al. (2007). "Promoter hypermethylation silences expression of the HoxA4 gene and correlates with IgVh mutational status in CLL". Leukemia. 20 (7): 1326–9. doi:10.1038/sj.leu.2404254. PMID 16688227.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• HOXA4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.