HOXB7

Homeobox B7
File:PBB Protein HOXB7 image.jpg PDB rendering based on 1ahd.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1ahd​, 1hom​, 1san​, 2hoa​, 9ant​
Identifiers
Symbols	HOXB7 ; HOX2; HHO.C1; HOX2C; Hox-2.3
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55828
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE HOXB7 204778 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Homeobox B7, also known as HOXB7, is a human gene.

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.

See also

• Homeobox

Further reading

• Scott MP (1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. PMID 1358459.
• Baier LJ, Hannibal MC, Hanley EW, Nabel GJ (1991). "Lymphoid expression and TATAA binding of a human protein containing an Antennapedia homeodomain". Blood. 78 (4): 1047–55. PMID 1678287.CS1 maint: Multiple names: authors list (link)
• McAlpine PJ, Shows TB (1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. PMID 1973146.
• Peverali FA, D'Esposito M, Acampora D; et al. (1991). "Expression of HOX homeogenes in human neuroblastoma cell culture lines". Differentiation. 45 (1): 61–9. PMID 1981366.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Giampaolo A, Acampora D, Zappavigna V; et al. (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation. 40 (3): 191–7. PMID 2570724.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shen WF, Largman C, Lowney P; et al. (1989). "Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines". Proc. Natl. Acad. Sci. U.S.A. 86 (21): 8536–40. PMID 2573064.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Acampora D, D'Esposito M, Faiella A; et al. (1990). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402. PMID 2574852.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boncinelli E, Acampora D, Pannese M; et al. (1990). "Organization of human class I homeobox genes". Genome. 31 (2): 745–56. PMID 2576652.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Simeone A, Mavilio F, Acampora D; et al. (1987). "Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development". Proc. Natl. Acad. Sci. U.S.A. 84 (14): 4914–8. PMID 2885844.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lill MC, Fuller JF, Herzig R; et al. (1995). "The role of the homeobox gene, HOX B7, in human myelomonocytic differentiation". Blood. 85 (3): 692–7. PMID 7530503.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chang CP, Shen WF, Rozenfeld S; et al. (1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. 9 (6): 663–74. PMID 7729685.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Corsetti MT, Levi G, Lancia F; et al. (1995). "Nucleolar localisation of three Hox homeoproteins". J. Cell. Sci. 108 ( Pt 1): 187–93. PMID 7738096.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Inamori K, Takeshita K, Chiba S; et al. (1993). "Identification of homeobox genes expressed in human T-lymphocytes". Biochem. Biophys. Res. Commun. 196 (1): 203–8. doi:10.1006/bbrc.1993.2235. PMID 8105782.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Miano JM, Firulli AB, Olson EN; et al. (1996). "Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells". Proc. Natl. Acad. Sci. U.S.A. 93 (2): 900–5. PMID 8570656.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Apiou F, Flagiello D, Cillo C; et al. (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–5. PMID 8646877.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Caré A, Silvani A, Meccia E; et al. (1996). "HOXB7 constitutively activates basic fibroblast growth factor in melanomas". Mol. Cell. Biol. 16 (9): 4842–51. PMID 8756643.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• LeBrun DP, Matthews BP, Feldman BJ, Cleary ML (1997). "The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains". Oncogene. 15 (17): 2059–67. doi:10.1038/sj.onc.1201367. PMID 9366523.CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stelnicki EJ, Kömüves LG, Kwong AO; et al. (1998). "HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development". J. Invest. Dermatol. 110 (2): 110–5. doi:10.1046/j.1523-1747.1998.00092.x. PMID 9457903.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• HOXB7+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.