IRF2

Interferon regulatory factor 2
PDB rendering based on 1irf.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1irf​, 1irg​, 2irf​
Identifiers
Symbols	IRF2 ; DKFZp686F0244; IRF-2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1659
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Interferon regulatory factor 2, also known as IRF2, is a human gene.

IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.

See also

• IRF1
• Interferon regulatory factors

Further reading

• Harada H, Taniguchi T, Tanaka N (1999). "The role of interferon regulatory factors in the interferon system and cell growth control". Biochimie. 80 (8–9): 641–50. PMID 9865486.CS1 maint: Multiple names: authors list (link)
• Pitha PM, Au WC, Lowther W; et al. (1999). "Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth". Biochimie. 80 (8–9): 651–8. PMID 9865487.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Harada H, Fujita T, Miyamoto M; et al. (1989). "Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes". Cell. 58 (4): 729–39. PMID 2475256.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Itoh S, Harada H, Fujita T; et al. (1989). "Sequence of a cDNA coding for human IRF-2". Nucleic Acids Res. 17 (20): 8372. PMID 2813069.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Harada H, Takahashi E, Itoh S; et al. (1994). "Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system". Mol. Cell. Biol. 14 (2): 1500–9. PMID 7507207.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Adams MD, Kerlavage AR, Fleischmann RD; et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence". Nature. 377 (6547 Suppl): 3–174. PMID 7566098.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sharf R, Azriel A, Lejbkowicz F; et al. (1995). "Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factors". J. Biol. Chem. 270 (22): 13063–9. PMID 7768900.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cha Y, Deisseroth AB (1994). "Human interferon regulatory factor 2 gene. Intron-exon organization and functional analysis of 5'-flanking region". J. Biol. Chem. 269 (7): 5279–87. PMID 8106512.
• Harada H, Kitagawa M, Tanaka N; et al. (1993). "Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2". Science. 259 (5097): 971–4. PMID 8438157.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Drew PD, Franzoso G, Carlson LM; et al. (1996). "Interferon regulatory factor-2 physically interacts with NF-kappa B in vitro and inhibits NF-kappa B induction of major histocompatibility class I and beta 2-microglobulin gene expression in transfected human neuroblastoma cells". J. Neuroimmunol. 63 (2): 157–62. PMID 8550813.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Birnbaum MJ, van Zundert B, Vaughan PS; et al. (1997). "Phosphorylation of the oncogenic transcription factor interferon regulatory factor 2 (IRF2) in vitro and in vivo". J. Cell. Biochem. 66 (2): 175–83. PMID 9213219.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Masumi A, Wang IM, Lefebvre B; et al. (1999). "The histone acetylase PCAF is a phorbol-ester-inducible coactivator of the IRF family that confers enhanced interferon responsiveness". Mol. Cell. Biol. 19 (3): 1810–20. PMID 10022868.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li W, Nagineni CN, Hooks JJ; et al. (1999). "Interferon-gamma signaling in human retinal pigment epithelial cells mediated by STAT1, ICSBP, and IRF-1 transcription factors". Invest. Ophthalmol. Vis. Sci. 40 (5): 976–82. PMID 10102295.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Whitney LW, Becker KG, Tresser NJ; et al. (1999). "Analysis of gene expression in mutiple sclerosis lesions using cDNA microarrays". Ann. Neurol. 46 (3): 425–8. PMID 10482277.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mild GC, Schmahl GE, Shayan P, Niemeyer CM (2000). "Expression of interferon regulatory factor 1 and 2 in hematopoietic cells of children with juvenile myelomonocytic leukemia". Leuk. Lymphoma. 35 (5–6): 507–11. PMID 10609788.CS1 maint: Multiple names: authors list (link)
• Staal A, Enserink JM, Stein JL; et al. (2000). "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2". J. Cell. Physiol. 185 (2): 269–79. doi:10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L. PMID 11025449.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Larrea E, Alberdi A, Castelruiz Y; et al. (2001). "Expression of interferon-alpha subtypes in peripheral mononuclear cells from patients with chronic hepatitis C: a role for interferon-alpha5". J. Viral Hepat. 8 (2): 103–10. PMID 11264730.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Masumi A, Ozato K (2001). "Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment". J. Biol. Chem. 276 (24): 20973–80. doi:10.1074/jbc.M101707200. PMID 11304541.

External links

• IRF2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.