KLF4

Kruppel-like factor 4 (gut)
Identifiers
Symbols	KLF4 ; EZF; GKLF
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3123
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE KLF4 221841 s at tn.png
File:PBB GE KLF4 220266 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Kruppel-like factor 4 (gut), also known as KLF4, is a human gene.

See also

• Kruppel-like factors

Further reading

• Rowland BD, Peeper DS (2006). "KLF4, p21 and context-dependent opposing forces in cancer". Nat. Rev. Cancer. 6 (1): 11–23. doi:10.1038/nrc1780. PMID 16372018.
• Shields JM, Christy RJ, Yang VW (1996). "Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest". J. Biol. Chem. 271 (33): 20009–17. PMID 8702718.CS1 maint: Multiple names: authors list (link)
• Garrett-Sinha LA, Eberspaecher H, Seldin MF, de Crombrugghe B (1997). "A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells". J. Biol. Chem. 271 (49): 31384–90. PMID 8940147.CS1 maint: Multiple names: authors list (link)
• Yet SF, McA'Nulty MM, Folta SC; et al. (1998). "Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains". J. Biol. Chem. 273 (2): 1026–31. PMID 9422764.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang W, Shields JM, Sogawa K; et al. (1998). "The gut-enriched Krüppel-like factor suppresses the activity of the CYP1A1 promoter in an Sp1-dependent fashion". J. Biol. Chem. 273 (28): 17917–25. PMID 9651398.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Foster KW, Ren S, Louro ID; et al. (1999). "Oncogene expression cloning by retroviral transduction of adenovirus E1A-immortalized rat kidney RK3E cells: transformation of a host with epithelial features by c-MYC and the zinc finger protein GKLF". Cell Growth Differ. 10 (6): 423–34. PMID 10392904.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Segre JA, Bauer C, Fuchs E (1999). "Klf4 is a transcription factor required for establishing the barrier function of the skin". Nat. Genet. 22 (4): 356–60. doi:10.1038/11926. PMID 10431239.CS1 maint: Multiple names: authors list (link)
• Geiman DE, Ton-That H, Johnson JM, Yang VW (2000). "Transactivation and growth suppression by the gut-enriched Krüppel-like factor (Krüppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction". Nucleic Acids Res. 28 (5): 1106–13. PMID 10666450.CS1 maint: Multiple names: authors list (link)
• Zhang W, Geiman DE, Shields JM; et al. (2000). "The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter". J. Biol. Chem. 275 (24): 18391–8. doi:10.1074/jbc.C000062200. PMID 10749849.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Okano J, Opitz OG, Nakagawa H; et al. (2000). "The Krüppel-like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interact". FEBS Lett. 473 (1): 95–100. PMID 10802067.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Higaki Y, Schullery D, Kawata Y; et al. (2002). "Synergistic activation of the rat laminin gamma1 chain promoter by the gut-enriched Kruppel-like factor (GKLF/KLF4) and Sp1". Nucleic Acids Res. 30 (11): 2270–9. PMID 12034813.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen ZY, Shie JL, Tseng CC (2003). "Gut-enriched Kruppel-like factor represses ornithine decarboxylase gene expression and functions as checkpoint regulator in colonic cancer cells". J. Biol. Chem. 277 (48): 46831–9. doi:10.1074/jbc.M204816200. PMID 12297499.CS1 maint: Multiple names: authors list (link)
• Yoon HS, Chen X, Yang VW (2003). "Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage". J. Biol. Chem. 278 (4): 2101–5. doi:10.1074/jbc.M211027200. PMID 12427745.CS1 maint: Multiple names: authors list (link)
• Wang N, Liu ZH, Ding F; et al. (2003). "Down-regulation of gut-enriched Kruppel-like factor expression in esophageal cancer". World J. Gastroenterol. 8 (6): 966–70. PMID 12439907.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen X, Whitney EM, Gao SY, Yang VW (2003). "Transcriptional profiling of Krüppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation". J. Mol. Biol. 326 (3): 665–77. PMID 12581631.CS1 maint: Multiple names: authors list (link)
• Dang DT, Chen X, Feng J; et al. (2003). "Overexpression of Krüppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity". Oncogene. 22 (22): 3424–30. doi:10.1038/sj.onc.1206413. PMID 12776194.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mao Z, Song S, Zhu Y; et al. (2003). "Transcriptional regulation of A33 antigen expression by gut-enriched Krüppel-like factor". Oncogene. 22 (28): 4434–43. doi:10.1038/sj.onc.1206508. PMID 12853980.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohnishi S, Ohnami S, Laub F; et al. (2003). "Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer". Biochem. Biophys. Res. Commun. 308 (2): 251–6. PMID 12901861.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hinnebusch BF, Siddique A, Henderson JW; et al. (2004). "Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor". Am. J. Physiol. Gastrointest. Liver Physiol. 286 (1): G23–30. doi:10.1152/ajpgi.00203.2003. PMID 12919939.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• KLF4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.