LHX3

LIM homeobox 3
Identifiers
Symbols	LHX3 ; DKFZp762A2013; M2-LHX3
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7814
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE LHX3 221670 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

LIM homeobox 3, also known as LHX3, is a human gene.

This gene encodes a member a large protein family which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Mutations in this gene have been associated with a syndrome of combined pituitary hormone deficiency and rigid cervical spine. Two transcripts variants encoding distinct isoforms have been identified for this gene.

Further reading

• Zhadanov AB, Bertuzzi S, Taira M; et al. (1995). "Expression pattern of the murine LIM class homeobox gene Lhx3 in subsets of neural and neuroendocrine tissues". Dev. Dyn. 202 (4): 354–64. doi:10.1002/aja.1002020405. PMID 7626792.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhadanov AB, Copeland NG, Gilbert DJ; et al. (1995). "Genomic structure and chromosomal localization of the mouse LIM/homeobox gene Lhx3". Genomics. 27 (1): 27–32. doi:10.1006/geno.1995.1004. PMID 7665181.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jurata LW, Pfaff SL, Gill GN (1998). "The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors". J. Biol. Chem. 273 (6): 3152–7. PMID 9452425.CS1 maint: Multiple names: authors list (link)
• Bach I, Rodriguez-Esteban C, Carrière C; et al. (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex". Nat. Genet. 22 (4): 394–9. doi:10.1038/11970. PMID 10431247.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Glenn DJ, Maurer RA (2000). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". J. Biol. Chem. 274 (51): 36159–67. PMID 10593900.
• Sloop KW, Meier BC, Bridwell JL; et al. (2000). "Differential activation of pituitary hormone genes by human Lhx3 isoforms with distinct DNA binding properties". Mol. Endocrinol. 13 (12): 2212–25. PMID 10598593.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sloop KW, Showalter AD, Von Kap-Herr C; et al. (2000). "Analysis of the human LHX3 neuroendocrine transcription factor gene and mapping to the subtelomeric region of chromosome 9". Gene. 245 (2): 237–43. PMID 10717474.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Howard PW, Maurer RA (2000). "Identification of a conserved protein that interacts with specific LIM homeodomain transcription factors". J. Biol. Chem. 275 (18): 13336–42. PMID 10788441.
• Parker GE, Sandoval RM, Feister HA; et al. (2000). "The homeodomain coordinates nuclear entry of the Lhx3 neuroendocrine transcription factor and association with the nuclear matrix". J. Biol. Chem. 275 (31): 23891–8. doi:10.1074/jbc.M000377200. PMID 10818088.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Netchine I, Sobrier ML, Krude H; et al. (2000). "Mutations in LHX3 result in a new syndrome revealed by combined pituitary hormone deficiency". Nat. Genet. 25 (2): 182–6. doi:10.1038/76041. PMID 10835633.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schmitt S, Biason-Lauber A, Betts D, Schoenle EJ (2000). "Genomic structure, chromosomal localization, and expression pattern of the human LIM-homeobox3 (LHX 3) gene". Biochem. Biophys. Res. Commun. 274 (1): 49–56. doi:10.1006/bbrc.2000.3038. PMID 10903894.CS1 maint: Multiple names: authors list (link)
• Sloop KW, Dwyer CJ, Rhodes SJ (2001). "An isoform-specific inhibitory domain regulates the LHX3 LIM homeodomain factor holoprotein and the production of a functional alternate translation form". J. Biol. Chem. 276 (39): 36311–9. doi:10.1074/jbc.M103888200. PMID 11470784.CS1 maint: Multiple names: authors list (link)
• Ostendorff HP, Peirano RI, Peters MA; et al. (2002). "Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors". Nature. 416 (6876): 99–103. doi:10.1038/416099a. PMID 11882901.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• van Meyel DJ, Thomas JB, Agulnick AD (2003). "Ssdp proteins bind to LIM-interacting co-factors and regulate the activity of LIM-homeodomain protein complexes in vivo". Development. 130 (9): 1915–25. PMID 12642495.CS1 maint: Multiple names: authors list (link)
• Kim SS, Kim Y, Shin YL; et al. (2004). "Clinical characteristics and molecular analysis of PIT1, PROP1,LHX3, and HESX1 in combined pituitary hormone deficiency patients with abnormal pituitary MR imaging". Horm. Res. 60 (6): 277–83. doi:10.1159/000074245. PMID 14646405.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dattani MT (2004). "Borjeson-Forssman-Lehmann syndrome: a novel pituitary phenotype due to mutation in a novel gene". J. Pediatr. Endocrinol. Metab. 16 (9): 1207–9. PMID 14714741.
• West BE, Parker GE, Savage JJ; et al. (2004). "Regulation of the follicle-stimulating hormone beta gene by the LHX3 LIM-homeodomain transcription factor". Endocrinology. 145 (11): 4866–79. doi:10.1210/en.2004-0598. PMID 15271874.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Parker GE, West BE, Witzmann FA, Rhodes SJ (2005). "Serine/threonine/tyrosine phosphorylation of the LHX3 LIM-homeodomain transcription factor". J. Cell. Biochem. 94 (1): 67–80. doi:10.1002/jcb.20287. PMID 15517599.CS1 maint: Multiple names: authors list (link)
• Sobrier ML, Attié-Bitach T, Netchine I; et al. (2006). "Pathophysiology of syndromic combined pituitary hormone deficiency due to a LHX3 defect in light of LHX3 and LHX4 expression during early human development". Gene Expr. Patterns. 5 (2): 279–84. doi:10.1016/j.modgep.2004.07.003. PMID 15567726.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• LHX3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.