MYCL1
| V-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | MYCL1 ; LMYC; MYCL | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 3921 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE MYCL1 214058 at tn.png | |||||||||||
| File:PBB GE MYCL1 215491 at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
V-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian), also known as MYCL1, is a human gene.[1]
MYCL1 is a bHLH (basic helix-loop-helix) transcription factor implicated in lung cancer.[2]
References
- ↑ "Entrez Gene: MYCL1 v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)".
- ↑ Ikegaki N, Minna J, Kennett RH (1989). "The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences". EMBO J. 8 (6): 1793–9. PMID 2548855.
Further reading
- Lüscher B (2001). "Function and regulation of the transcription factors of the Myc/Max/Mad network". Gene. 277 (1–2): 1–14. PMID 11602341.
- Ikegaki N, Minna J, Kennett RH (1989). "The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences". EMBO J. 8 (6): 1793–9. PMID 2548855.
- Kaye F, Battey J, Nau M; et al. (1988). "Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing". Mol. Cell. Biol. 8 (1): 186–95. PMID 2827002.
- De Greve J, Battey J, Fedorko J; et al. (1988). "The human L-myc gene encodes multiple nuclear phosphoproteins from alternatively processed mRNAs". Mol. Cell. Biol. 8 (10): 4381–8. PMID 3054516.
- DePinho RA, Hatton KS, Tesfaye A; et al. (1988). "The human myc gene family: structure and activity of L-myc and an L-myc pseudogene". Genes Dev. 1 (10): 1311–26. PMID 3322939.
- Atchley WR, Fitch WM (1995). "Myc and Max: molecular evolution of a family of proto-oncogene products and their dimerization partner". Proc. Natl. Acad. Sci. U.S.A. 92 (22): 10217–21. PMID 7479755.
- Speleman F, Van Camp G, Van Roy N (1997). "Reassignment of MYCL1 to human chromosome 1p34.3 by fluorescence in situ hybridization". Cytogenet. Cell Genet. 72 (2–3): 189–90. PMID 8978772.
- FitzGerald MJ, Arsura M, Bellas RE; et al. (1999). "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc". Oncogene. 18 (15): 2489–98. doi:10.1038/sj.onc.1202611. PMID 10229200.
- Kumimoto H, Hamajima N, Nishimoto Y; et al. (2002). "L-myc genotype is associated with different susceptibility to lung cancer in smokers". Jpn. J. Cancer Res. 93 (1): 1–5. PMID 11802801.
- Suzuki H, Yamashiro K (2002). "L-myc restriction fragment length polymorphism and histological pattern of invasion in lung adenocarcinoma". Oncol. Rep. 9 (2): 345–7. PMID 11836605.
- Primdahl H, von der Maase H, Christensen M; et al. (2002). "Allelic deletions of Rb and L-myc in urine sediments from patients with bladder tumors or carcinoma in situ". Oncol. Rep. 9 (3): 551–5. PMID 11956626.
- Demopoulos K, Arvanitis DA, Vassilakis DA; et al. (2003). "MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmonary fibrosis". J. Cell. Mol. Med. 6 (2): 215–22. PMID 12169206.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Wu R, Lin L, Beer DG; et al. (2003). "Amplification and overexpression of the L-MYC proto-oncogene in ovarian carcinomas". Am. J. Pathol. 162 (5): 1603–10. PMID 12707044.
- Kambara T, Sharp GB, Nagasaka T; et al. (2004). "Allelic loss of a common microsatellite marker MYCL1: a useful prognostic factor of poor outcomes in colorectal cancer". Clin. Cancer Res. 10 (5): 1758–63. PMID 15014029.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
- Spinola M, Falvella FS, Galvan A; et al. (2007). "Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival". Lung Cancer. 55 (3): 271–7. doi:10.1016/j.lungcan.2006.10.023. PMID 17145094.
External links
- MYCL1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.