NFATC2

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
File:PBB Protein NFATC2 image.jpg PDB rendering based on 1a02.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1a02​, 1owr​, 1p7h​, 1pzu​, 1s9k​, 2as5​
Identifiers
Symbols	NFATC2 ; KIAA0611; NFAT1; NFATP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7861
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2, also known as NFATC2, is a human gene.

This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

See also

• NFAT

Further reading

• Rao A, Luo C, Hogan PG (1997). "Transcription factors of the NFAT family: regulation and function". Annu. Rev. Immunol. 15: 707–47. doi:10.1146/annurev.immunol.15.1.707. PMID 9143705.CS1 maint: Multiple names: authors list (link)
• Crabtree GR (1999). "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT". Cell. 96 (5): 611–4. PMID 10089876.
• Horsley V, Pavlath GK (2002). "NFAT: ubiquitous regulator of cell differentiation and adaptation". J. Cell Biol. 156 (5): 771–4. doi:10.1083/jcb.200111073. PMID 11877454.
• Aramburu J, Azzoni L, Rao A, Perussia B (1995). "Activation and expression of the nuclear factors of activated T cells, NFATp and NFATc, in human natural killer cells: regulation upon CD16 ligand binding". J. Exp. Med. 182 (3): 801–10. PMID 7650486.CS1 maint: Multiple names: authors list (link)
• Auffray C, Behar G, Bois F; et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". C. R. Acad. Sci. III, Sci. Vie. 318 (2): 263–72. PMID 7757816.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li X, Ho SN, Luna J; et al. (1995). "Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp". Cytogenet. Cell Genet. 68 (3–4): 185–91. PMID 7842733.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ho S, Timmerman L, Northrop J, Crabtree GR (1995). "Cloning and characterization of NF-ATc and NF-ATp: the cytoplasmic components of NF-AT". Adv. Exp. Med. Biol. 365: 167–73. PMID 7887301.CS1 maint: Multiple names: authors list (link)
• Jabado N, Le Deist F, Fisher A, Hivroz C (1994). "Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity". Eur. J. Immunol. 24 (11): 2646–52. PMID 7957556.CS1 maint: Multiple names: authors list (link)
• Vacca A, Farina M, Maroder M; et al. (1995). "Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif". Biochem. Biophys. Res. Commun. 205 (1): 467–74. doi:10.1006/bbrc.1994.2689. PMID 7999066.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Northrop JP, Ho SN, Chen L; et al. (1994). "NF-AT components define a family of transcription factors targeted in T-cell activation". Nature. 369 (6480): 497–502. doi:10.1038/369497a0. PMID 8202141.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jain J, McCaffrey PG, Miner Z; et al. (1993). "The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun". Nature. 365 (6444): 352–5. doi:10.1038/365352a0. PMID 8397339.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Luo C, Burgeon E, Carew JA; et al. (1996). "Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes". Mol. Cell. Biol. 16 (7): 3955–66. PMID 8668213.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Di Somma MM, Majolini MB, Burastero SE; et al. (1996). "Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering". Eur. J. Immunol. 26 (9): 2181–8. PMID 8814265.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Copeland KF, McKay PJ, Rosenthal KL (1996). "Suppression of the human immunodeficiency virus long terminal repeat by CD8+ T cells is dependent on the NFAT-1 element". AIDS Res. Hum. Retroviruses. 12 (2): 143–8. PMID 8834464.CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Hodge MR, Chun HJ, Rengarajan J; et al. (1997). "NF-AT-Driven interleukin-4 transcription potentiated by NIP45". Science. 274 (5294): 1903–5. PMID 8943202.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lyakh L, Ghosh P, Rice NR (1997). "Expression of NFAT-family proteins in normal human T cells". Mol. Cell. Biol. 17 (5): 2475–84. PMID 9111316.CS1 maint: Multiple names: authors list (link)
• Amasaki Y, Masuda ES, Imamura R; et al. (1998). "Distinct NFAT family proteins are involved in the nuclear NFAT-DNA binding complexes from human thymocyte subsets". J. Immunol. 160 (5): 2324–33. PMID 9498773.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen L, Glover JN, Hogan PG; et al. (1998). "Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA". Nature. 392 (6671): 42–8. doi:10.1038/32100. PMID 9510247.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• NFATC2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.