NKX3-1
| NK3 transcription factor related, locus 1 (Drosophila) | |||||||||||
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| Identifiers | |||||||||||
| Symbols | NKX3-1 ; BAPX2; NKX3; NKX3.1; NKX3A | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 4494 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE NKX3-1 209706 at tn.png | |||||||||||
| File:PBB GE NKX3-1 211497 x at tn.png | |||||||||||
| File:PBB GE NKX3-1 211498 s at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
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NK3 transcription factor related, locus 1 (Drosophila), also known as NKX3-1, is a human gene.
The homeodomain-containing transcription factor NKX3A is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3A protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia.[supplied by OMIM][1]
References
Further reading
- Shen MM, Abate-Shen C (2004). "Roles of the Nkx3.1 homeobox gene in prostate organogenesis and carcinogenesis". Dev. Dyn. 228 (4): 767–78. doi:10.1002/dvdy.10397. PMID 14648854.
- Abdulkadir SA (2006). "Mechanisms of prostate tumorigenesis: roles for transcription factors Nkx3.1 and Egr1". Ann. N. Y. Acad. Sci. 1059: 33–40. doi:10.1196/annals.1339.018. PMID 16382041.
- He WW, Sciavolino PJ, Wing J; et al. (1997). "A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer". Genomics. 43 (1): 69–77. doi:10.1006/geno.1997.4715. PMID 9226374.
- Voeller HJ, Augustus M, Madike V; et al. (1997). "Coding region of NKX3.1, a prostate-specific homeobox gene on 8p21, is not mutated in human prostate cancers". Cancer Res. 57 (20): 4455–9. PMID 9377551.
- Prescott JL, Blok L, Tindall DJ (1998). "Isolation and androgen regulation of the human homeobox cDNA, NKX3.1". Prostate. 35 (1): 71–80. PMID 9537602.
- Choi CY, Kim YH, Kwon HJ, Kim Y (1999). "The homeodomain protein NK-3 recruits Groucho and a histone deacetylase complex to repress transcription". J. Biol. Chem. 274 (47): 33194–7. PMID 10559189.
- Carson JA, Fillmore RA, Schwartz RJ, Zimmer WE (2001). "The smooth muscle gamma-actin gene promoter is a molecular target for the mouse bagpipe homologue, mNkx3-1, and serum response factor". J. Biol. Chem. 275 (50): 39061–72. doi:10.1074/jbc.M006532200. PMID 10993896.
- Bowen C, Bubendorf L, Voeller HJ; et al. (2000). "Loss of NKX3.1 expression in human prostate cancers correlates with tumor progression". Cancer Res. 60 (21): 6111–5. PMID 11085535.
- Korkmaz KS, Korkmaz CG, Ragnhildstveit E; et al. (2001). "Full-length cDNA sequence and genomic organization of human NKX3A - alternative forms and regulation by both androgens and estrogens". Gene. 260 (1–2): 25–36. PMID 11137288.
- Chen H, Nandi AK, Li X, Bieberich CJ (2002). "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter". Cancer Res. 62 (2): 338–40. PMID 11809674.
- Filmore RA, Dean DA, Zimmer WE (2003). "The smooth muscle gamma-actin gene is androgen responsive in prostate epithelia". Gene Expr. 10 (5–6): 201–11. PMID 12450213.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Gelmann EP, Bowen C, Bubendorf L (2003). "Expression of NKX3.1 in normal and malignant tissues". Prostate. 55 (2): 111–7. doi:10.1002/pros.10210. PMID 12661036.
- Skotheim RI, Korkmaz KS, Klokk TI; et al. (2004). "NKX3.1 expression is lost in testicular germ cell tumors". Am. J. Pathol. 163 (6): 2149–54. PMID 14633588.
- Korkmaz CG, Korkmaz KS, Manola J; et al. (2004). "Analysis of androgen regulated homeobox gene NKX3.1 during prostate carcinogenesis". J. Urol. 172 (3): 1134–9. doi:10.1097/01.ju.0000136526.78535.b8. PMID 15311057.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Chen H, Bieberich CJ (2005). "Structural and functional analysis of domains mediating interaction between NKX-3.1 and PDEF". J. Cell. Biochem. 94 (1): 168–77. doi:10.1002/jcb.20297. PMID 15523673.
- Lind GE, Skotheim RI, Fraga MF; et al. (2005). "The loss of NKX3.1 expression in testicular--and prostate--cancers is not caused by promoter hypermethylation". Mol. Cancer. 4 (1): 8. doi:10.1186/1476-4598-4-8. PMID 15691383.
- Asatiani E, Huang WX, Wang A; et al. (2005). "Deletion, methylation, and expression of the NKX3.1 suppressor gene in primary human prostate cancer". Cancer Res. 65 (4): 1164–73. doi:10.1158/0008-5472.CAN-04-2688. PMID 15734999.
External links
- NKX3-1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.