PITX1

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Paired-like homeodomain transcription factor 1
File:PBB Protein PITX1 image.jpg
PDB rendering based on 1yz8.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols PITX1 ; PTX1; BFT; POTX
External IDs Template:OMIM5 Template:MGI HomoloGene: 20584
RNA expression pattern
File:PBB GE PITX1 209587 at tn.png
File:PBB GE PITX1 208502 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Paired-like homeodomain transcription factor 1, also known as PITX1, is a human gene.[1]

This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin [1] and it could be associated with autism[2]

References

  1. ↑ 1.0 1.1 "Entrez Gene: PITX1 paired-like homeodomain transcription factor 1".
  2. ↑ Philippi, Anne; Tores, Frédéric; Carayol, Jérome; Rousseau, Francis (2007), "Association of autism with polymorphisms in the paired-like homeodomain t ranscription factor 1 (PITX1) on chromosome 5q31: a candidate gene analysis.", BMC Med. Genet., 8, pp. 741471-2350–8-74, doi:10.1186/1471-2350-8-7418053270, PMID:18053270 line feed character in |title= at position 74 (help)

Further reading

  • Szeto DP, Ryan AK, O'Connell SM, Rosenfeld MG (1996). "P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 7706–10. PMID 8755540.
  • Shang J, Li X, Ring HZ; et al. (1997). "Backfoot, a novel homeobox gene, maps to human chromosome 5 (BFT) and mouse chromosome 13 (Bft)". Genomics. 40 (1): 108–13. doi:10.1006/geno.1996.4558. PMID 9070926.
  • Shang J, Luo Y, Clayton DA (1997). "Backfoot is a novel homeobox gene expressed in the mesenchyme of developing hind limb". Dev. Dyn. 209 (2): 242–53. doi:10.1002/(SICI)1097-0177(199706)209:2<242::AID-AJA10>3.0.CO;2-0. PMID 9186059.
  • Crawford MJ, Lanctôt C, Tremblay JJ; et al. (1998). "Human and murine PTX1/Ptx1 gene maps to the region for Treacher Collins syndrome". Mamm. Genome. 8 (11): 841–5. PMID 9337397.
  • Poulin G, Turgeon B, Drouin J (1997). "NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene". Mol. Cell. Biol. 17 (11): 6673–82. PMID 9343431.
  • Tremblay JJ, Drouin J (1999). "Egr-1 is a downstream effector of GnRH and synergizes by direct interaction with Ptx1 and SF-1 to enhance luteinizing hormone beta gene transcription". Mol. Cell. Biol. 19 (4): 2567–76. PMID 10082522.
  • Tremblay JJ, Marcil A, Gauthier Y, Drouin J (1999). "Ptx1 regulates SF-1 activity by an interaction that mimics the role of the ligand-binding domain". EMBO J. 18 (12): 3431–41. doi:10.1093/emboj/18.12.3431. PMID 10369682.
  • Pellegrini-Bouiller I, Manrique C, Gunz G; et al. (1999). "Expression of the members of the Ptx family of transcription factors in human pituitary adenomas". J. Clin. Endocrinol. Metab. 84 (6): 2212–20. PMID 10372733.
  • Tahara S, Kurotani R, Sanno N; et al. (2001). "Expression of pituitary homeo box 1 (Ptx1) in human non-neoplastic pituitaries and pituitary adenomas". Mod. Pathol. 13 (10): 1097–108. doi:10.1038/modpathol.3880204. PMID 11048804.
  • Quentien MH, Manfroid I, Moncet D; et al. (2003). "Pitx factors are involved in basal and hormone-regulated activity of the human prolactin promoter". J. Biol. Chem. 277 (46): 44408–16. doi:10.1074/jbc.M207824200. PMID 12223489.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Ghosh AK, Majumder M, Steele R; et al. (2003). "Modulation of interferon expression by hepatitis C virus NS5A protein and human homeodomain protein PTX1". Virology. 306 (1): 51–9. PMID 12620797.
  • Hiroi N, Kino T, Bassett M; et al. (2004). "Pituitary homeobox factor 1, a novel transcription factor in the adrenal regulating steroid 11beta-hydroxylase". Horm. Metab. Res. 35 (5): 273–8. doi:10.1055/s-2003-41301. PMID 12915995.
  • Schmutz J, Martin J, Terry A; et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5". Nature. 431 (7006): 268–74. doi:10.1038/nature02919. PMID 15372022.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Kolfschoten IG, van Leeuwen B, Berns K; et al. (2005). "A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity". Cell. 121 (6): 849–58. doi:10.1016/j.cell.2005.04.017. PMID 15960973.
  • Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Lord RV, Brabender J, Wickramasinghe K; et al. (2006). "Increased CDX2 and decreased PITX1 homeobox gene expression in Barrett's esophagus and Barrett's-associated adenocarcinoma". Surgery. 138 (5): 924–31. doi:10.1016/j.surg.2005.05.007. PMID 16291394.
  • Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Picard C, Azeddine B, Moldovan F; et al. (2007). "New emerging role of pitx1 transcription factor in osteoarthritis pathogenesis". Clin. Orthop. Relat. Res. 462: 59–66. doi:10.1097/BLO.0b013e3180d09d9c. PMID 17549029.

External links


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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