PRDM2
| PR domain containing 2, with ZNF domain | |||||||||||
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| Identifiers | |||||||||||
| Symbols | PRDM2 ; HUMHOXY1; MTB-ZF; RIZ; RIZ1; RIZ2 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 40822 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE PRDM2 203056 s at tn.png | |||||||||||
| File:PBB GE PRDM2 216433 s at tn.png | |||||||||||
| File:PBB GE PRDM2 203057 s at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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PR domain containing 2, with ZNF domain, also known as PRDM2, is a human gene.[1]
This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Three transcript variants encoding different isoforms have been found for this gene.[1]
References
Further reading
- Buyse IM, Shao G, Huang S (1995). "The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein". Proc. Natl. Acad. Sci. U.S.A. 92 (10): 4467–71. PMID 7538672.
- Shapiro VS, Lee P, Winoto A (1995). "Identification and cloning of the G3B cDNA encoding a 3' segment of a protein binding to GATA-3". Gene. 163 (2): 329–30. PMID 7590293.
- Muraosa Y, Takahashi K, Yoshizawa M, Shibahara S (1996). "cDNA cloning of a novel protein containing two zinc-finger domains that may function as a transcription factor for the human heme-oxygenase-1 gene". Eur. J. Biochem. 235 (3): 471–9. PMID 8654390.
- Buyse IM, Takahashi EI, Huang S (1996). "Physical mapping of the retinoblastoma interacting zinc finger gene RIZ to D1S228 on chromosome 1p36". Genomics. 34 (1): 119–21. doi:10.1006/geno.1996.0249. PMID 8661032.
- Liu L, Shao G, Steele-Perkins G, Huang S (1997). "The retinoblastoma interacting zinc finger gene RIZ produces a PR domain-lacking product through an internal promoter". J. Biol. Chem. 272 (5): 2984–91. PMID 9006946.
- Xie M, Shao G, Buyse IM, Huang S (1997). "Transcriptional repression mediated by the PR domain zinc finger gene RIZ". J. Biol. Chem. 272 (42): 26360–6. PMID 9334209.
- He L, Yu JX, Liu L; et al. (1998). "RIZ1, but not the alternative RIZ2 product of the same gene, is underexpressed in breast cancer, and forced RIZ1 expression causes G2-M cell cycle arrest and/or apoptosis". Cancer Res. 58 (19): 4238–44. PMID 9766644.
- Abbondanza C, Medici N, Nigro V; et al. (2000). "The retinoblastoma-interacting zinc-finger protein RIZ is a downstream effector of estrogen action". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3130–5. doi:10.1073/pnas.050015697. PMID 10706618.
- Dias Neto E, Correa RG, Verjovski-Almeida S; et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.
- Du Y, Carling T, Fang W; et al. (2001). "Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyltransferase superfamily". Cancer Res. 61 (22): 8094–9. PMID 11719434.
- Sasaki O, Meguro K, Tohmiya Y; et al. (2003). "Nucleotide alteration of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukemia". Tohoku J. Exp. Med. 196 (3): 193–201. PMID 12002276.
- Poetsch M, Dittberner T, Woenckhaus C (2002). "Frameshift mutations of RIZ, but no point mutations in RIZ1 exons in malignant melanomas with deletions in 1p36". Oncogene. 21 (19): 3038–42. doi:10.1038/sj.onc.1205457. PMID 12082534.
- Sasaki O, Meguro K, Tohmiya Y; et al. (2003). "Altered expression of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukaemia". Br. J. Haematol. 119 (4): 940–8. PMID 12472571.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Tokumaru Y, Nomoto S, Jerónimo C; et al. (2003). "Biallelic inactivation of the RIZ1 gene in human gastric cancer". Oncogene. 22 (44): 6954–8. doi:10.1038/sj.onc.1206403. PMID 14534544.
- Kim KC, Geng L, Huang S (2004). "Inactivation of a histone methyltransferase by mutations in human cancers". Cancer Res. 63 (22): 7619–23. PMID 14633678.
- Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
- Pan KF, Lu YY, Liu WG; et al. (2004). "Detection of frameshift mutations of RIZ in gastric cancers with microsatellite instability". World J. Gastroenterol. 10 (18): 2719–22. PMID 15309726.
- Rossi M, Abbondanza C, D'Arcangelo A; et al. (2004). "The Zn-finger domain of RIZ protein promotes MCF-7 cell proliferation". Cancer Lett. 215 (2): 229–37. doi:10.1016/j.canlet.2004.05.014. PMID 15488642.
- Grundberg E, Carling T, Brändström H; et al. (2005). "A deletion polymorphism in the RIZ gene, a female sex steroid hormone receptor coactivator, exhibits decreased response to estrogen in vitro and associates with low bone mineral density in young Swedish women". J. Clin. Endocrinol. Metab. 89 (12): 6173–8. doi:10.1210/jc.2004-0403. PMID 15579774.
External links
- PRDM2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.