Retinoic acid receptor gamma
Retinoic acid receptor, gamma | |||||||||||||
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File:PBB Protein RARG image.jpg PDB rendering based on 1dsz. | |||||||||||||
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Identifiers | |||||||||||||
Symbols | RARG ; NR1B3; RARC | ||||||||||||
External IDs | Template:OMIM5 Template:MGI HomoloGene: 20263 | ||||||||||||
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Orthologs | |||||||||||||
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Species | Human | Mouse | |||||||||||
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RefSeq (protein) | n/a | n/a | |||||||||||
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PubMed search | n/a | n/a |
Retinoic acid receptor gamma (RAR-gamma), also known as NR1B3 (nuclear receptor subfamily 1, group B, member 3) is a nuclear receptor encoded by the RARG gene.[1]
See also
References
Further reading
- Leid M, Kastner P, Lyons R; et al. (1992). "Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently". Cell. 68 (2): 377–95. PMID 1310259.
- Vollberg TM, Nervi C, George MD; et al. (1992). "Retinoic acid receptors as regulators of human epidermal keratinocyte differentiation". Mol. Endocrinol. 6 (5): 667–76. PMID 1318502.
- Lehmann JM, Zhang XK, Pfahl M (1992). "RAR gamma 2 expression is regulated through a retinoic acid response element embedded in Sp1 sites". Mol. Cell. Biol. 12 (7): 2976–85. PMID 1320193.
- Mattei MG, Rivière M, Krust A; et al. (1991). "Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes". Genomics. 10 (4): 1061–9. PMID 1655630.
- Lehmann JM, Hoffmann B, Pfahl M (1991). "Genomic organization of the retinoic acid receptor gamma gene". Nucleic Acids Res. 19 (3): 573–8. PMID 1849262.
- Kastner P, Krust A, Mendelsohn C; et al. (1990). "Murine isoforms of retinoic acid receptor gamma with specific patterns of expression". Proc. Natl. Acad. Sci. U.S.A. 87 (7): 2700–4. PMID 2157210.
- Giguère V, Shago M, Zirngibl R; et al. (1990). "Identification of a novel isoform of the retinoic acid receptor gamma expressed in the mouse embryo". Mol. Cell. Biol. 10 (5): 2335–40. PMID 2157970.
- Ishikawa T, Umesono K, Mangelsdorf DJ; et al. (1990). "A functional retinoic acid receptor encoded by the gene on human chromosome 12". Mol. Endocrinol. 4 (6): 837–44. PMID 2172793.
- Krust A, Kastner P, Petkovich M; et al. (1989). "A third human retinoic acid receptor, hRAR-gamma". Proc. Natl. Acad. Sci. U.S.A. 86 (14): 5310–4. PMID 2546152.
- Renaud JP, Rochel N, Ruff M; et al. (1996). "Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid". Nature. 378 (6558): 681–9. doi:10.1038/378681a0. PMID 7501014.
- Zhou L, Pang J, Munroe DG, Lau C (1993). "A human retinoic acid receptor gamma isoform is homologous to the murine retinoic acid receptor gamma 7". Nucleic Acids Res. 21 (10): 2520. PMID 7685085.
- Zitnik RJ, Kotloff RM, Latifpour J; et al. (1994). "Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts". J. Immunol. 152 (3): 1419–27. PMID 8301142.
- Botling J, Castro DS, Oberg F; et al. (1997). "Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation". J. Biol. Chem. 272 (14): 9443–9. PMID 9083083.
- Lømo J, Smeland EB, Ulven S; et al. (1998). "RAR-, not RXR, ligands inhibit cell activation and prevent apoptosis in B-lymphocytes". J. Cell. Physiol. 175 (1): 68–77. doi:10.1002/(SICI)1097-4652(199804)175:1<68::AID-JCP8>3.0.CO;2-A. PMID 9491782.
- Klaholz BP, Renaud JP, Mitschler A; et al. (1998). "Conformational adaptation of agonists to the human nuclear receptor RAR gamma". Nat. Struct. Biol. 5 (3): 199–202. PMID 9501913.
- Zhang ZP, Gambone CJ, Gabriel JL; et al. (1999). "Arg278, but not Lys229 or Lys236, plays an important role in the binding of retinoic acid by retinoic acid receptor gamma". J. Biol. Chem. 273 (51): 34016–21. PMID 9852056.
- Yang C, Zhou D, Chen S (1999). "Modulation of aromatase expression in the breast tissue by ERR alpha-1 orphan receptor". Cancer Res. 58 (24): 5695–700. PMID 9865725.
- Nagpal S, Ghosn C, DiSepio D; et al. (1999). "Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor". J. Biol. Chem. 274 (32): 22563–8. PMID 10428834.
- Egea PF, Mitschler A, Rochel N; et al. (2000). "Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid". EMBO J. 19 (11): 2592–601. doi:10.1093/emboj/19.11.2592. PMID 10835357.
- Boudjelal M, Voorhees JJ, Fisher GJ (2002). "Retinoid signaling is attenuated by proteasome-mediated degradation of retinoid receptors in human keratinocyte HaCaT cells". Exp. Cell Res. 274 (1): 130–7. doi:10.1006/excr.2001.5450. PMID 11855864.
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