BMAL
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| aryl hydrocarbon receptor nuclear translocator-like | |
|---|---|
| Identifiers | |
| Symbol | ARNTL |
| Entrez | 406 |
| HUGO | 701 |
| OMIM | 602550 |
| RefSeq | NM_001178 |
| UniProt | O00327 |
| Other data | |
| Locus | Chr. 11 p15 |
| aryl hydrocarbon receptor nuclear translocator-like 2 | |
|---|---|
| Identifiers | |
| Symbol | ARNTL2 |
| Entrez | 56938 |
| HUGO | 18984 |
| RefSeq | NM_020183 |
| UniProt | Q8WYA4 |
| Other data | |
| Locus | Chr. 12 p12.2-11.2 |
Bmal (brain and muscle aryl hydrocarbon receptor nuclear translocator (ARNT)-like) is a gene which encodes proteins regulating circadian rhythm. BMAL proteins form part of a basic-helix-loop-helix transcription factor. BMAL-1 dimerizes with CLOCK in vivo and transactivates gene expression of Period and Timeless in drosophila by binding to E-box elements in their promoters.[1] BMAL1-CLOCK also regulates Cryptochrome genes (e.g. Cry1, Cry2) and Period genes (e.g. Per1, Per2, Per3).[2] Bmal itself is downregulated by Period expression.
See also
References
External links
- BMAL1+protein at the US National Library of Medicine Medical Subject Headings (MeSH)
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