ESR2

See also: Estrogen receptor

Estrogen receptor 2 (ER beta)
PDB rendering based on 1hj1.
Identifiers
Symbols	ESR2 ; ER-BETA; ESR-BETA; ESRB; ESTRB; Erb; NR3A2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1100
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Estrogen receptor beta (ER-beta), also known as NR3A2 (nuclear receptor subfamily 3, group A, member 2), is a nuclear receptor which is activated by the sex hormone estrogen. ER-beta is encoded by the human gene ESR2 (EStrogen Receptor 2).

This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.

Further reading

• Pettersson K, Gustafsson JA (2001). "Role of estrogen receptor beta in estrogen action". Annu. Rev. Physiol. 63: 165–92. doi:10.1146/annurev.physiol.63.1.165. PMID 11181953.
• Warner M, Saji S, Gustafsson JA (2004). "The normal and malignant mammary gland: a fresh look with ER beta onboard". Journal of mammary gland biology and neoplasia. 5 (3): 289–94. PMID 14973391.CS1 maint: Multiple names: authors list (link)
• Saxon LK, Turner CH (2005). "Estrogen receptor beta: the antimechanostat?". Bone. 36 (2): 185–92. doi:10.1016/j.bone.2004.08.003. PMID 15780944.
• Halachmi S, Marden E, Martin G; et al. (1994). "Estrogen receptor-associated proteins: possible mediators of hormone-induced transcription". Science. 264 (5164): 1455–8. PMID 8197458.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schwabe JW, Chapman L, Finch JT, Rhodes D (1993). "The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements". Cell. 75 (3): 567–78. PMID 8221895.CS1 maint: Multiple names: authors list (link)
• Mosselman S, Polman J, Dijkema R (1996). "ER beta: identification and characterization of a novel human estrogen receptor". FEBS Lett. 392 (1): 49–53. PMID 8769313.CS1 maint: Multiple names: authors list (link)
• Chen H, Lin RJ, Schiltz RL; et al. (1997). "Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300". Cell. 90 (3): 569–80. PMID 9267036.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pace P, Taylor J, Suntharalingam S; et al. (1997). "Human estrogen receptor beta binds DNA in a manner similar to and dimerizes with estrogen receptor alpha". J. Biol. Chem. 272 (41): 25832–8. PMID 9325313.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brandenberger AW, Tee MK, Lee JY; et al. (1997). "Tissue distribution of estrogen receptors alpha (ER-alpha) and beta (ER-beta) mRNA in the midgestational human fetus". J. Clin. Endocrinol. Metab. 82 (10): 3509–12. PMID 9329394.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Enmark E, Pelto-Huikko M, Grandien K; et al. (1998). "Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern". J. Clin. Endocrinol. Metab. 82 (12): 4258–65. PMID 9398750.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vladusic EA, Hornby AE, Guerra-Vladusic FK, Lupu R (1998). "Expression of estrogen receptor beta messenger RNA variant in breast cancer". Cancer Res. 58 (2): 210–4. PMID 9443393.CS1 maint: Multiple names: authors list (link)
• Ogawa S, Inoue S, Watanabe T; et al. (1998). "The complete primary structure of human estrogen receptor beta (hER beta) and its heterodimerization with ER alpha in vivo and in vitro". Biochem. Biophys. Res. Commun. 243 (1): 122–6. doi:10.1006/bbrc.1997.7893. PMID 9473491.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Alves SE, Lopez V, McEwen BS, Weiland NG (1998). "Differential colocalization of estrogen receptor beta (ERbeta) with oxytocin and vasopressin in the paraventricular and supraoptic nuclei of the female rat brain: an immunocytochemical study". Proc. Natl. Acad. Sci. U.S.A. 95 (6): 3281–6. PMID 9501254.CS1 maint: Multiple names: authors list (link)
• Brandenberger AW, Tee MK, Jaffe RB (1998). "Estrogen receptor alpha (ER-alpha) and beta (ER-beta) mRNAs in normal ovary, ovarian serous cystadenocarcinoma and ovarian cancer cell lines: down-regulation of ER-beta in neoplastic tissues". J. Clin. Endocrinol. Metab. 83 (3): 1025–8. PMID 9506768.CS1 maint: Multiple names: authors list (link)
• Moore JT, McKee DD, Slentz-Kesler K; et al. (1998). "Cloning and characterization of human estrogen receptor beta isoforms". Biochem. Biophys. Res. Commun. 247 (1): 75–8. doi:10.1006/bbrc.1998.8738. PMID 9636657.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ogawa S, Inoue S, Watanabe T; et al. (1998). "Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor ofestrogen action in human". Nucleic Acids Res. 26 (15): 3505–12. PMID 9671811.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lu B, Leygue E, Dotzlaw H; et al. (1998). "Estrogen receptor-beta mRNA variants in human and murine tissues". Mol. Cell. Endocrinol. 138 (1–2): 199–203. PMID 9685228.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Seol W, Hanstein B, Brown M, Moore DD (1998). "Inhibition of estrogen receptor action by the orphan receptor SHP (short heterodimer partner)". Mol. Endocrinol. 12 (10): 1551–7. PMID 9773978.CS1 maint: Multiple names: authors list (link)
• Hanstein B, Liu H, Yancisin MC, Brown M (1999). "Functional analysis of a novel estrogen receptor-beta isoform". Mol. Endocrinol. 13 (1): 129–37. PMID 9892018.CS1 maint: Multiple names: authors list (link)
• Vidal O, Kindblom LG, Ohlsson C (1999). "Expression and localization of estrogen receptor-beta in murine and human bone". J. Bone Miner. Res. 14 (6): 923–9. PMID 10352100.CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.