Neurogenin-3

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Neurogenin-3 is a protein that in humans is encoded by the NEUROG3 gene.[1]

Neurogenin-3 is expressed in endocrine progenitor cells and is required for endocrine cell development in the pancreas and intestine.[2] It belongs to a family of basic helix-loop-helix (bHLH) transcription factors involved in the determination of neural precursor cells in the neuroectoderm.[3]

Neurogenin 3 (NGN3) is expressed by 2-10% of acinar and duct cells in the histologically normal adult human pancreas. NGN3+ cells isolated from cultured exocrine tissue by coexpressed cell surface glycoprotein CD133 have a transcriptome consistent with exocrine dedifferentiation, a phenotype that resembles endocrine progenitor cells during development, and a capacity for endocrine differentiation in vitro.[4] Human[5] and rodent[6][7][8][9][10][11][12][13][14] exocrine cells have been reprogrammed into cells with an islet cell-like phenotype following direct expression of NGN3 or manipulation that leads to its expression.

Detail

Much more at Neurogenins#Neurogenin-3

References

  1. ↑ "Entrez Gene: neurogenin 3".
  2. ↑ Wang J, Cortina G, Wu SV, Tran R, Cho JH, Tsai MJ, Bailey TJ, Jamrich M, Ament ME, Treem WR, Hill ID, Vargas JH, Gershman G, Farmer DG, Reyen L, Martín MG (Jul 2006). "Mutant neurogenin-3 in congenital malabsorptive diarrhea". The New England Journal of Medicine. 355 (3): 270–80. doi:10.1056/NEJMoa054288. PMID 16855267.
  3. ↑ Gradwohl G, Dierich A, LeMeur M, Guillemot F (Feb 2000). "neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas". Proceedings of the National Academy of Sciences of the United States of America. 97 (4): 1607–11. doi:10.1073/pnas.97.4.1607. PMC 26482. PMID 10677506.
  4. ↑ Gomez DL, O'Driscoll M, Sheets TP, Hruban RH, Oberholzer J, McGarrigle JJ, Shamblott MJ (2015). "Neurogenin 3 Expressing Cells in the Human Exocrine Pancreas Have the Capacity for Endocrine Cell Fate". PLOS ONE. 10 (8): e0133862. doi:10.1371/journal.pone.0133862. PMC 4545947. PMID 26288179.
  5. ↑ Swales N, Martens GA, Bonné S, Heremans Y, Borup R, Van de Casteele M, Ling Z, Pipeleers D, Ravassard P, Nielsen F, Ferrer J, Heimberg H (2012). "Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming". PLOS ONE. 7 (5): e37055. doi:10.1371/journal.pone.0037055. PMC 3351393. PMID 22606327.
  6. ↑ Xu X, D'Hoker J, Stangé G, Bonné S, De Leu N, Xiao X, Van de Casteele M, Mellitzer G, Ling Z, Pipeleers D, Bouwens L, Scharfmann R, Gradwohl G, Heimberg H (Jan 2008). "Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas". Cell. 132 (2): 197–207. doi:10.1016/j.cell.2007.12.015. PMID 18243096.
  7. ↑ Van de Casteele M, Leuckx G, Baeyens L, Cai Y, Yuchi Y, Coppens V, De Groef S, Eriksson M, Svensson C, Ahlgren U, Ahnfelt-Rønne J, Madsen OD, Waisman A, Dor Y, Jensen JN, Heimberg H (7 March 2013). "Neurogenin 3+ cells contribute to β-cell neogenesis and proliferation in injured adult mouse pancreas". Cell Death & Disease. 4: e523. doi:10.1038/cddis.2013.52. PMC 3613830. PMID 23470530.
  8. ↑ Figeac F, Ilias A, Bailbe D, Portha B, Movassat J (Oct 2012). "Local in vivo GSK3β knockdown promotes pancreatic β cell and acinar cell regeneration in 90% pancreatectomized rat". Molecular Therapy. 20 (10): 1944–52. doi:10.1038/mt.2012.112. PMC 3464647. PMID 22828498.
  9. ↑ Li WC, Rukstalis JM, Nishimura W, Tchipashvili V, Habener JF, Sharma A, Bonner-Weir S (Aug 2010). "Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats". Journal of Cell Science. 123 (Pt 16): 2792–802. doi:10.1242/jcs.065268. PMC 2915881. PMID 20663919.
  10. ↑ Baeyens L, Lemper M, Leuckx G, De Groef S, Bonfanti P, Stangé G, Shemer R, Nord C, Scheel DW, Pan FC, Ahlgren U, Gu G, Stoffers DA, Dor Y, Ferrer J, Gradwohl G, Wright CV, Van de Casteele M, German MS, Bouwens L, Heimberg H (Jan 2014). "Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice". Nature Biotechnology. 32 (1): 76–83. doi:10.1038/nbt.2747. PMC 4096987. PMID 24240391.
  11. ↑ Baeyens L, Bonné S, German MS, Ravassard P, Heimberg H, Bouwens L (Nov 2006). "Ngn3 expression during postnatal in vitro beta cell neogenesis induced by the JAK/STAT pathway". Cell Death and Differentiation. 13 (11): 1892–9. doi:10.1038/sj.cdd.4401883. PMID 16514419.
  12. ↑ Lemper M, Leuckx G, Heremans Y, German MS, Heimberg H, Bouwens L, Baeyens L (Jul 2015). "Reprogramming of human pancreatic exocrine cells to β-like cells". Cell Death and Differentiation. 22 (7): 1117–30. doi:10.1038/cdd.2014.193. PMC 4572860. PMID 25476775.
  13. ↑ Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA (Oct 2008). "In vivo reprogramming of adult pancreatic exocrine cells to beta-cells". Nature. 455 (7213): 627–32. doi:10.1038/nature07314. PMID 18754011.
  14. ↑ Sancho R, Gruber R, Gu G, Behrens A (Aug 2014). "Loss of Fbw7 reprograms adult pancreatic ductal cells into α, δ, and β cells". Cell Stem Cell. 15 (2): 139–53. doi:10.1016/j.stem.2014.06.019. PMC 4136739. PMID 25105579.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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